with edematous predominance].
In all of the cases analyzed, a differential diagnosis was performed between EG and Warfarin-induced skin necrosis, cocaine-induced skin necrosis, calciphylaxis, septic emboli, loxoscelism
, diabetic microangiopathy, disseminated intravascular coagulation, necrotizing vasculitis, paraneoplastic extensive necrotizing vasculitis, pyoderma gangrenosum, livedoid vasculopathy, necrotizing fasciitis, and necrosis secondary to the use of vasoactive drugs.
intermedia is widespread in human domestic habitats and its bite causes a public health problem known as loxoscelism
(Fischer, 1994; Fischer and VasconcellosNeto, 2005a; Marques-da-Silva et al.
All of these are often falsely attributed to loxoscelism
In fact, these critical molecular messengers are involved in the genesis of a constellation of human pathophysiological phenomena: stroke, pericarditis, peritonitis, loxoscelism
, meningitis, sepsis, coagulation disorders, myocardial dysfunction, and circulatory collapse (16-19).
There are two types of skin loxoscelism
, the necrotic (75%) and edematous (4%) .
Because some bites cause systemic loxoscelism
, clinicians should be familiar with its manifestations.
Reported treatments for loxoscelism
include hyperbaric oxygen, dapsone, antihistamines, antibiotics, dextran, glucocorticosteroids, vasodilators, heparin, nitroglycerin, electric shock, curettage, and surgical excision, but "none of these has been proved effective," Dr.
Proper knowledge of the spider's habitat and lifestyle as well as the signs and symptoms of loxoscelism
are needed to assess clinical cases adequately.
Progression of loxoscelism
also is characterized by the "red, white, and blue sign," with concentric zones of erythema enclosing an area of ischemia, which in turn surrounds a smaller area of bluish impending necrosis, he said.
The pathogenesis of systemic loxoscelism
following brown recluse spider bites.
The spiders of the genus Loxosceles are ubiquitously infamous throughout the world because of their ability to occasionally cause significant skin necrosis also known as cutaneous loxoscelism