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lowest-observed-adverse-effect level

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lowest-observed-adverse-effect level
Toxicology The lowest concentration of a chemical in a study, or group of studies, that produces statistically or biologically significant ↑ in frequency or severity of adverse effects between the exposed population and an appropriate control. See Ames test. Cf No-observed-adverse-effect level.


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Environmental Protection Agency, which is based on a lowest-observed-adverse-effect level of 50 milligrams per kilogram per day.
Kosatasky and Foran (1996) discussed the need to revise downward the WHO lowest-observed-adverse-effect level (LOAEL) for mercury of > 200 ppb blood mercury equivalent because the historic fish consumption studies do not support this value.
However, the panel did compare, when appropriate, its analyses to existing no-observed-adverse-effect levels (NOAELs) or lowest-observed-adverse-effect levels (LOAELs) reported by the U.
 
 
 
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