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lower esophageal sphincter |
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lower esophageal sphincter, the terminal few centimeters of the esophagus, near the esophagogastric junction, which normally remain constricted except during swallowing and prevent reflux of gastric contents into the esophagus. lower esophageal sphincter A 3-5 cm in length zone of ↑ pressure at the junction of the distal esophagus with the gastric cardia, located at the hiatus, which forms a physical barrier in preventing gastric reflux; substances that ↑
the LES tone include gastrin, acetylcholine, serotonin, PGF2 a, motilin, substance P, histamine, pancreatic polypeptide How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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2) Factors predisposing to stricture formation are not well understood, but studies demonstrate that patients with peptic stricture are older, have reflux symptoms of longer duration, have an associated esophageal motility disorder, and have significantly reduced lower esophageal sphincter pressures. One reason gastric reflux occurs in runners is the transient relaxation of the lower esophageal sphincter secondary to the swallowing of air. Potential Etiologies for Running-Related Gastroesophageal Reflux Lower Esophageal Sphincter Relaxation |
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