low-grade squamous intraepithelial lesion


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Related to low-grade squamous intraepithelial lesion: HPV, colposcopy

low-grade squamous intraepithelial lesion (LGSIL, LSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effect and mild dysplasia (cervical intraepithelial neoplasia grade 1).
See also: Bethesda system, reactive changes, ASCUS, atypical glandular cells of undetermined significance.

low-grade squamous intraepithelial lesion

Gynecologic cytology A lesion of the uterine cervix which is characterized by cells occurring singly or in sheets, nuclear abnormalities in cells with mature cytoplasm, bi- or multinucleation, well-defined optically clear perinuclear halo, distinct cell borders and others that translate into either HPV infection or mild dysplasia–CIN 1 of uterine cervix–a diagnosis made on biopsied tissue. Cf High-grade squamous intraepithelial lesion.

low-grade squa·mous in·tra·ep·i·the·li·al le·sion

(LGSIL, LSIL) (lō-grād skwā'mŭs in'tră-ep'i-thē'lē-ăl lē'zhŭn)
Term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effects and mild dysplasia (cervical intraepithelial neoplasia grade 1).
See also: Bethesda system, reactive changes, ASCUS, atypical glandular cells of undetermined significance

low-grade squamous intraepithelial lesion

Abbreviation: LGSIL
A cytological abnormality found in Papanicolaou tests (Pap tests) where there are early mild changes in the epithelial cells covering the outside of the cervix. Causes include infection with human papillomavirus, cervical trauma, or postmenopausal changes. Risk factors include intercourse with multiple sex partners or a partner with multiple sex partners, unprotected sex at a young age, history of sexually transmitted disease, and tobacco use. About 60% of LGSIL will spontaneously resolve. If left untreated, a small number of women eventually develop cervical cancer.
See also: lesion
References in periodicals archive ?
Low-grade squamous intraepithelial lesions (LSIL) were seen in 57%, atypical squamous cells of undetermined significance (ASCUS) in 30%, high-grade squamous intraepithelial lesions (HSIL) in 7%, and atypical squamous cells in which HSIL cannot be excluded (ASCH) in 5.
60 Notes: ASCUS, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesions.
Low-grade squamous intraepithelial lesions (LSIL) were seen in 57% atypical squamous cells of undetermined significance (ASCUS) in 30%, high-grade squamous intraepithelial lesions (HSIL) in 7%, and atypical squamous cells in which HSIL cannot be excluded (ASC-H) in 5.
The phase II study was done at about 19 centers, where more than 300 women were screened after being flagged as having low-grade squamous intraepithelial lesions by a routine Pap smear.
The study's primary efficacy end point was full resolution of low-grade squamous intraepithelial lesions on a later Pap smear.
BALTIMORE -- Watchful observation by cytology, rather than colposcopy, may be the most appropriate way to manage low-grade squamous intraepithelial lesions in adolescent women because the overwhelming majority of these lesions clear in 36-40 months.
Low-grade squamous intraepithelial lesions (LSIL), the most common manifestation of human papillomavirus (HPV) infection, persist or progress to high-grade lesions or cancer in 20%-30% of adults, Dr.
Colposcopies performed on all the women during pregnancy confirmed the presence of high-grade squamous intraepithelial lesions (HGSILs) in 30 patients, low-grade squamous intraepithelial lesions (LGSILs) in 53 patients, and atypical squamous cells of undetermined significance (ASCUS) in 17 patients.
The overwhelming majority of low-grade squamous intraepithelial lesions will spontaneously regress in this age group, as well as a high proportion of those found to have CIN 2 and 3 on cervical biopsy.
Compared with the conventional Pap smears, ThinPrep was associated with more than a twofold increase in the diagnosis of low-grade squamous intraepithelial lesions (odds ratio 2.
It's not clear whether the increased costs of ThinPrep are offset by the fact that it results in fewer inadequate smears and more accurate detection of low-grade squamous intraepithelial lesions, allowing for earlier treatment, added Dr.
Performing HPV typing on all Pap smears would be unnecessary, he explained, because smear results that are high-grade squamous intraepithelial lesions (HGSIL) require immediate colposcopy, while low-grade squamous intraepithelial lesions (LGSIL) are likely to regress spontaneously Those LGSIL that persist for more than a year should be colposcoped.

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