low-density lipoprotein receptor disorder

low-density lipoprotein (LDL) receptor disorder,

an inherited disorder transmitted as a dominant trait and characterized by a high level of serum cholesterol, tendinous xanthomas, and early evidence of atherosclerosis, especially of the coronary arteries. Affected individuals at 50 years of age have 3 to 10 times greater risk of ischemic heart disease than the general population. Cholesterol levels are elevated at birth, increase with age, and average 250 to 500 mg/dL in heterozygous adults and 500 to 1000 mg/dL in adults who are homozygous for the gene. Xanthomas begin to appear at 20 years of age and occur most frequently on the Achilles tendon, extensor tendons of the hands, elbows, and tibial tuberosities. In type IIA familial hypercholesterolemia, only low-density lipoprotein (LDL) level is elevated, whereas in type IIB LDL and very low-density lipoprotein levels are increased. The disorder occurs in Caucasians, African-Americans, and Asian-Americans; the prevalence of the gene in the United States is 1:1000. Treatment includes a low-cholesterol and low-saturated fat diet. Cholestyramine may be given to patients with type IIA familial hypercholesterolemia but not to those with type IIB. Also called familial hypercholesterolemia. hypercholesterolemic xanthomatosis, hyperlipidemia type IIA, hyperlipidemia type IIB.

Mentioned in	?		Medical browser	?		Full browser	?
apolipoprotein test ezetimibe familial hypercholesterolemia HMG-CoA reductase hypercholesterolemic xanthomatosis hyperlipidemia type IIA rosuvastatin			low dose effect Low Fat low fat diet Low Fat Snack Food low forceps Low Impact Sport low lip line low magnesium low motion disease low muscle tone low phosphate low potassium low sugar low T3 syndrome low T4 syndrome Low transverse incision low vision aids low-birth weight infant low-calcium diet low-caloric diet low-cholesterol diet low-compliance bladder low-cost physician low-density lipoprotein low-density lipoprotein cholesterol low-density lipoprotein receptor disorder low-dose aspirin low-dose tolerance low-energy defibrillation low-fat diet low-fat milk low-fiber diet low-flow breathing system low-flow oxygen delivery system low-flow oxygen therapy low-grade low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type low-grade fever low-grade infection low-grade lymphoma low-grade squamous intraepithelial lesion low-impact sport low-level language low-level waste low-lying placenta low-molecular weight heparin low-molecular-weight heparin low-osmolality contrast medium low-output gastrointestinal fistula low-output heart failure low-power field			Low-Cost Robot by means of Integrated Servo Control Low-Cost Sonobuoy/Seeker Low-Cost Tooling for Composites Low-Cost Tow Target Low-Cost Weapon Delivery System Low-cost Windows low-country Low-coupon bond refunding low-cut Low-cut filter Low-cut filter Low-definition television Low-Delay Advanced Audio Compression Low-Delay Code-Excited Linear Prediction Low-Delay Data Low-Delay Embedded Transmission low-density low-density concrete low-density dynamite Low-Density Epidermal Cells low-density lipoprotein low-density lipoprotein low-density lipoprotein low-density lipoprotein cholesterol low-density lipoprotein cholesterol Low-Density Lipoprotein Particle Size low-density lipoprotein r low-density lipoprotein r low-density lipoprotein r low-density lipoprotein r low-density lipoprotein receptor disorder Low-Density Lipoprotein Receptor-Deficient low-density lipoproteins low-density lipoproteins Low-Density Membrane Fraction Low-Density Parity Check low-density polyethylene low-density polyethylene low-density polyethylene Low-Density Triton-Insoluble Low-density-lipoprotein Low-Dimensional Electron Gas Low-Dimensional Semiconductor Structure Low-doc Low-doc loan Low-Dosage Heparin Therapy Low-Dosage Hydrate Inhibitor low-dose aspirin Low-Dose BZD Low-Dose Chest Computed Tomographic Scanning Low-Dose Computed Tomography Low-Dose Dexamethasone Suppression Low-Dose Dexamethasone-Suppression Test Low-Dose Dobutamine Echocardiography Low-Dose Dobutamine Stress Echocardiography Low-Dose Dobutamine Ventriculography Low-Dose Heparin Low-Dose Inhaled Corticosteroids