loss of heterozygosity


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loss of heterozygosity

adjective Referring to a mutation that results in the loss of allelic uniqueness, often defined as a ≥ 40% increase in signal intensity of allelic signal.
References in periodicals archive ?
A poster describing a loss of heterozygosity and copy number changes in melanocytic lesions has been accepted for presentation at the 8th European Cytogenetics Conference, July 2-5, 2011, Porto, Portugal.
Over the last year, we have been using the Mapping 10K Array to identify regions of chromosomal amplification, deletion, and loss of heterozygosity in the same experiment, resulting in multiple publications," said Meyerson.
Loss of heterozygosity occurs when all or part of a chromosome is lost during the development of cancer.
promoter methylation), gene expression (mRNA), Loss of heterozygosity (LOH), microRNA, microsatellite instability, mitochondrial RNA (MtRNA), mutation of cell cycle genes (e.
Molecular evidence to support the classification of IDCP as a discrete entity comes from studies assessing loss of heterozygosity (LOH) at microsatellite loci often affected in PCa.
In the study, Ann Killary from the university and colleagues used a genetic technique termed 'suppression subtractive hybridization' to identify a new gene that is located on Chromosome 1 in a region where loss of heterozygosity (a specific type of genetic alteration) regularly occurs.
Commonly, miRNAs are located in cancer-associated genomic regions, including minimal regions of amplification, loss of heterozygosity, fragile sites, and common breakpoint regions in or near oncogenes or tumor suppressor genes (1).
In molluscan, similarly, several studies showed that no association was observed between selection or culture and loss of heterozygosity in the Pacific oyster Crassostrea gigas (Hedgecock & Sly 1990), hard clam Mercenaria mercenaria (Dillon & Manzi 1987) and American oyster C.
Currently available methods for isolating undegraded circulating DNA are limited, and there is a need to develop novel methods which improve the yield of undegraded DNA and to adapt detection assays so that this DNA can be used to detect mutations, microsatellite instabilities, loss of heterozygosity, epigenetic changes, and other molecular genetic changes.
The combined CGH-SNP platform allows the detection of copy number neutral or copy number gain, loss of heterozygosity and copy number variations in SNP deserts of the genome.
Chuaqui et al (6) analyzed loss of heterozygosity on chromosomes 5 and 17 in synchronous appendiceal and ovarian mucinous neoplasms obtained from 12 patients.
Archival formalin-fixed, paraffin-embedded tumor blocks frequently contain only low yields of amplifiable DNA, leading to false-positive data and poor reproducibility of loss of heterozygosity (LOH) in repeated experiments (11-13).