losartan


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Related to losartan: losartan potassium, losartan-hydrochlorothiazide

losartan

 [lo-sahr´tan]
an angiotensin II receptor antagonist used as an antihypertensive; used as the potassium salt.

losartan

/lo·sar·tan/ (lo-sahr´tan) an angiotensin II receptor antagonist, used as an antihypertensive; used as the potassium salt.

losartan

(lō-sär′tăn)
n.
An angiotensin II receptor blocker drug, C22H23ClN6O, used in the form of its potassium salt to treat hypertension.

losartan

an antihypertensive.
indications It is used to treat hypertension, either alone or in combination with other drugs.
contraindications Factors that prohibit the use of this drug are known hypersensitivity to tramadol and second- and third-trimester pregnancy.
adverse effects Life-threatening effects are cerebrovascular accident and myocardial infarction. Other adverse effects are anxiety, confusion, abnormal dreams, migraine, tremor, vertigo, task perversion, angina pectoris, second-degree atrioventricular block, hypotension, blurred vision, burning eyes, conjunctivitis, anorexia, constipation, dry mouth, flatulence, gastritis, vomiting, impotence, nocturia, urinary frequency, urinary tract infection, anemia, alopecia, dermatitis, dry skin, flushing, photosensitivity, rash, pruritus, sweating, gout, cramps, myalgia, pain, stiffness, congestion, dyspnea, and bronchitis. Common side effects are dizziness, insomnia, arrhythmias, diarrhea, dyspepsia, cough, and upper respiratory infection.

losartan

Cozaar® Pharmacology A sartan which blocks angiotensin II–A-II from binding to AT1, ↓ proteinuria and filtration fraction, inhibits secretion of aldosterone by the adrenal cortex, and ↑ uric acid excretion; in Pts with CHF, losartan ↓ afterload, ↑ cardiac output–effects shared by ACE inhibitors—and prevent left ventricular hypertrophy Side effects Vertigo. See Angiotensin II receptor antagonist, ELITE.

losartan

An angiotensin II antagonist drug used to treat high blood pressure (HYPERTENSION). In the LIFE trial of this drug, reported on in 2003, a subgroup of diabetic patients taking the drug showed a 37 percent reduction in mortality from heart attacks or strokes and a 39 percent reduction in overall mortality over people on other treatment. The drug appears to be effective in preventing sudden death from heart arrhythmias. A brand name is Cozaar. The drug is available combined with the diuretic drug HYDROCHLOROTHIAZIDE under the brand name Cozaar-Comp.
References in periodicals archive ?
Unlabeled uses include the treatment of congestive heart failure and, for losartan and irbesartan, diabetic nephropathy (2, 3).
The 4 studies of losartan monotherapy included a total of 1075 patients randomized to several doses of losartan and 334 to placebo.
After stopping the drugs for 2 months, as per protocol, about twice as many patients on telmisartan were reported to have experienced a slightly greater antiproteinuric effect, compared with those on losartan.
A prospective, randomised, double-blind, double-dummy, forced-titration, multicenter, parallel group, 1-year treatment trial to compare telMisartan 40 mg titrated to 80 mg versus losArtan 50 mg titrated to 100 mg, in hypertensive type 2 DiabEtic patients with Overt nephropathy.
Slagman MCJ, Nguyen TQ, Waanders F, Vogt L, Hemmelder MH, Oliver N, Navis GJ, Goldschmeding R, Laverman GD: Sodium restriction, losartan, and hydrochlorothiazide reduce elevated urinary CTGF/CCN-2 levels in patients with non-diabetic proteinuria [Abstract].
Then, each of those halves was divided into two more groups: one that received L-158,809, the compound similar to losartan, in its drinking water, and one group that received plain drinking water.
She presented preliminary data from a double-blind trial in which 261 patients from 51 sites were randomized to either placebo or losartan 50 mg/day for 4 weeks, titrated to 100 mg/day.
Food and Drug Administration has granted tentative approval for the Company's Abbreviated New Drug Application ("ANDA") for Losartan Potassium and Hydrochlorothiazide Tablets, 50 mg/12.
MADRID -- Angiotensin I receptor blockade with losartan improves insulin sensitivity independent of its effects on blood pressure in hypertensive individuals at risk for metabolic syndrome, reported Dr.
5 mg to 300 mg) or of Losartan 100 mg, a marketed angiotensin II receptor blocker.
FibroGen presented data from multiple studies designed to examine the effects of FG-3019 alone and in combination with current therapeutics, captopril (ACEi) and losartan (ARB), on diabetic vascular and cardiac complications including arterial passive stiffness, cardiac dysfunction, and vascular permeability.