loricrin


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loricrin

Dermatology An insoluble glycine/serine-rich transglutaminase substrate protein cross-linked to the cornified cell envelope of the upper dermis
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In immunohistochemistry study, the expression level of loricrin was higher in the upper epidermis of AD-like GVHD and LP-like GVHD patients, compared with HCs [Figure 4]a,[Figure 4]b,[Figure 4]c.
In parallel, keratin and filaggrin create the primary structural scaffold for the cornified lipid envelope, while involucrin and loricrin provide the filamentous framework for the binding of additional structural proteins and ceramides.
The increased expression of loricrin and involucrin suggested a different mechanism of skin barrier impairment from spontaneous AD.
The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope.
The proteins elafin, filaggrin, keratin intermediate filaments, loricrin and SPRs are isodipeptide crosslinked components of the human epidermal cornified cell envelope.
These events are finalized by the addition of loricrin to the existing involucrin-envoplakin scaffold.
Preliminary data suggest that transglutaminase 3 strongly favors cross-linking of loricrin and SPRs.
Progressive symmetrical erythrokeratoderma: report of a Turkish family and evaluation for loricrin and connexin gene mutations.
A molecular defect in loricrin, the major component of cornified cell envelope, underlies Vohwinkel's syndrome.