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a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.


Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B


Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.


Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment


• Hypersensitivity to drug


Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant patients

• children younger than age 2 (safety not established).


• Give once a day on empty stomach.

• Place rapidly disintegrating tablet on tongue; give with or without water.

• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections


Drug-food. Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.

• Assess patient's response to drug.

• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.

• Tell patient to report persistent or worsening symptoms.

• Instruct patient to report adverse reactions, such as headache or nervousness.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.


/lor·at·a·dine/ (lah-rat´ah-dēn) a nonsedating antihistamine used in the treatment of allergic rhinitis, chronic idiopathic urticaria, and asthma.


A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.


a nonsedating antihistamine (H1-receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma, administered orally.


An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.


Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.
References in periodicals archive ?
Aside from the sedation factor, diphenhydramine, loratadine, and cetirizine all may have similar side effects: dizziness, dry mouth, dry nose, dry eyes (these medication are all very drying agents) and constipation.
Loratadine is available over the counter for the treatment of seasonal and perennial allergic rhinitis as a tablet (10 mg) for children aged 6 and older and as a syrup (5 mg/ml) for children aged 2 to 5 years.
Because boys with first-degree hypospadias were excluded from the study, it is not possible to assess any link between loratadine exposure and the mildest form of the birth defect.
There was no association between loratadine use during the month before conception and the first trimester of pregnancy and an increased risk of hypospadias (MMWR 53110]:219-21, 2004).
which markets loratadine, says the company's own research shows no evidence that the drug promotes malignant tumor growth.
4) In the 30 days after the first prescription, the rate of all injuries was 308 per 1000 person years in the diphenhydramine cohort vs 137 per 1000 person-years in the loratadine cohort.
Recommended Dosage: One 10-mg loratadine tablet daily for adults and children older than 6 years.
Fexofenadine and loratadine are nonsedating agents, and acrivastine and cetirizine have low sedative properties.
Among the products the company makes in the United States are Loratadine (10 mg and orally dissolvable), Loratadine D24, Cetiri-zinc (10 mg), Acetaminophen (650 mg), Famotidine (10 mg and 20 mg strengths), Loperamide (2 mg) and Ibuprofen (200 mg).