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a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.


Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B


Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.


Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment


• Hypersensitivity to drug


Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).


• Give once a day on empty stomach.
• Place rapidly disintegrating tablet on tongue; give with or without water.
• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections


Drug-food.Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.
• Assess patient's response to drug.
• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.
• Tell patient to report persistent or worsening symptoms.
• Instruct patient to report adverse reactions, such as headache or nervousness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.


/lor·at·a·dine/ (lah-rat´ah-dēn) a nonsedating antihistamine used in the treatment of allergic rhinitis, chronic idiopathic urticaria, and asthma.


A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.


a nonsedating antihistamine (H1-receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma, administered orally.


An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.


Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.


n brand name: Claritin;
drug class: antihistamine, H1 histamine antagonist;
action: acts on blood vessels, gastrointestinal system, respiratory system by competing with histamine for H1-receptor site; decreases allergic response by blocking histamine;
uses: seasonal rhinitis, allergy symptoms, idiopathic chronic urticaria.
References in periodicals archive ?
Finally, van Cauwenberge et al (30) compared once-daily fexofenadine HCl 120 mg with loratadine 10 mg and placebo in the treatment of SAR in a multicenter, multinational, double-blind, parallel-group, randomized, placebo-controlled 2-week study (n = 688).
Loratadine is available over the counter for the treatment of seasonal and perennial allergic rhinitis as a tablet (10 mg) for children aged 6 and older and as a syrup (5 mg/ml) for children aged 2 to 5 years.
In the first part of both 30-second ads, Schering hyped the benefits of loratadine clearly and slowly in easy-to-understand language.
Loratadine and astemizole significantly boosted the growth of both melanoma and fibrosarcoma, and hydroxyzine promoted the development of just melanoma.
We still do not have enough data on loratadine and other newer antihistamines to reach the same conclusion with certainty, however, even though these agents are members of the same class and presumably work on the same histamine H1 receptors.
Loratadine was significantly more effective than placebo for most end points, except for nighttime symptoms and non-nose/non-eye symptoms.
Stabilization of the mast cells by cromolyn sodium and the antihistamine effects of loratadine and ranitidine may account for this regimen's effectiveness if indeed mast cell dysfunction is involved in the development of the syndrome.
33] The steroid fluticasone has been shown to be significantly more effective than the antihistamine loratadine in treating seasonal allergic rhinitis.
With the histamine blocking agent loratadine (Claritin) now available over the counter, many insurance companies are refusing to cover any second-generation antihistamine.
contains 10 mg of immediate-release loratadine and 240 mg of extended-release pseudoephedrine and has been approved for the relief of symptoms of seasonal allergic rhinitis.
CRx-197 is a selective cytokine modulator containing low concentrations of the allergy drug loratadine and the anti-depressant nortriptyline, neither of which is indicated for the treatment of dermatitis on its own but which have been shown to act synergistically in preclinical models of inflammation.