Furthermore, receiver operating characteristic (ROC) curve was built for the dose of IV loop diuretic
(furosemide) and the prediction of the aggravated renal dysfunction, i.
The most likely explanation for the short-term jump in risk of hip fracture may be related to the prominent urinary symptoms that often accompany a new prescription for loop diuretics
Tetracycline Antiseptics Acetic acid Alcohol Chlorhexidine Cresylate Gentian violet Vehicles Benzalkonium chloride Polyethylene glycol Propylene glycol Salicylates Nonsteroidal anti-inflammatory drugs Quinine Chemotherapeutic drugs Carboplatinum Cisplatinum Vinblastine Vincristine Loop diuretics
Ethacrynic acid Furosemide Table 2 Agents that protect against ototoxicity Alpha lipoic acid Antioxidants Calcium Fosfomycin Glutathione Iron chelators
Calcium (Ca), potassium (K), and magnesium (Mg) are depleted by loop diuretics
Ethacrynic acid is a loop diuretic
that was first introduced in the 1960s for treatment of congestive heart failure (CHF) and ascites (1-3) Although extremely potent, ethacrynic acid has been almost completely superseded by furosemide and bumetanide because ethacrynic acid has enhanced ototoxicity and vestibulotoxicity.
The adjusted odds ratio of an incident hip fracture was significantly increased by 80% during the 7 days following a new prescription for a loop diuretic
Patients who have evidence of symptomatic fluid overload should be treated with intravenous loop diuretics
Diuretics are divided into three subclasses: thiazide diuretics, loop diuretics
, and potassium-sparing diuretics.
Sulfa-containing nonantibiotics--including thiazides and loop diuretics
, as well as COX2 inhibitors--do not contain these same features.
The different diuretics include the loop diuretics
, thiazide diuretics, aldactone and osmotic agents.
NSAIDs may diminish the antihypertensive activity of thiazides, loop diuretics
, ACE inhibitors and angiotensin II antagonists.
angiotensin-converting enzyme inhibitors, cyclosporine, diuretics: loop diuretics
and thiazides; non-steroidal anti-inflammatory drugs, tetracycline), overdose, renal insufficiency, schizophrenia, surgery and volume depletion are among the factors that increase the risk for toxicity in previously stable patients (4).