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long-acting thyroid stimulator

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stimulator /stim·u·la·tor/ (stim´u-la″tor)
1. any agent that excites functional activity.
2. in electrodiagnosis, an instrument that applies pulses of current to stimulate a nerve, muscle, or area of the central nervous system.

long-acting thyroid stimulator  (LATS) thyroid-stimulating antibody associated with Graves disease; it is an autoantibody reactive against thyroid cell receptors for thyroid stimulating hormone and thus mimics the effects of the hormone.

long-acting thyroid stimulator
n. Abbr. LATS
A substance that is present in the blood of hyperthyroid patients and that exerts a prolonged stimulatory effect on the thyroid gland.

long-acting thyroid stimulator (LATS),
an immunoglobulin, probably an autoantibody, that exerts a prolonged stimulatory effect on the thyroid gland, causing rapid growth of the gland and excess thyroid function, resulting in hyperthyroidism. It is found circulating in the blood of 50% of people with Graves' disease.

long-acting thyroid stimulator (LATS)
a substance occurring in the blood in hyperthyroidism, having a stimulating effect on the thyroid of longer duration than that of thyrotropin. It is associated with immunoglobulin IgG and may function as an autoantibody.

long-acting thyroid stimulator
an autoantibody directed against thyroid-stimulating hormone receptors in the thyroid; abbreviated LATS. Its occurrence is associated with hyperthyroidism in humans.


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Kriss JP, Pleshakov V, Chien JR: Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema.
 
 
 
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