lodoxamide

lodoxamide

 [lo-dok´sah-mīd]
a mast cell stabilizer that inhibits immediate hypersensitivity, applied topically to the eye as the tromethamine salt for treatment of allergen-induced conjunctivitis, keratitis, and keratoconjunctivitis.

lodoxamide

/lo·dox·a·mide/ (lo-dok´sah-mīd) a mast cell stabilizer and antiallergic; applied topically to the eye as the tromethamine salt for the treatment of allergen-induced conjunctivitis, keratitis, and keratoconjunctivitis.

lodoxamide

[lo-dok′sämīd]
a mast cell stabilizer that inhibits immediate hypersensitivity, applied topically to the eye as the tromethamine salt for treatment of allergen-induced conjunctivitis, keratitis, and keratoconjunctivitis.

lodoxamide

A mast cell-stabilizing drug that prevents the release of HISTAMINE in allergic conditions, formulated as eye drops for the treatment of allergic CONJUNCTIVITIS. A brand name is Aldomide.

mast cell stabilizers

Prophylactic drugs used to treat allergic conjunctivitis, vernal conjunctivitis, giant pupillary conjunctivitis, superior limbic keratoconjunctivitis. They act by stabilizing the membranes of mast cells thus preventing the release of histamine. Common agents are sodium cromoglicate (cromolyn sodium), lodoxamide, nedocromil sodium, olopatadine hydrochloride and pemirolast potassium. See antihistamine; hypersensitivity.
References in periodicals archive ?
There are three drugs in this class that can be used topically in the eye: cromolyn, lodoxamide (Alomide), and nedocromil (Alocril).
1) Eleven trials that included 899 children and adults compared mast cell stabilizers (sodium cromoglycate, nedocromil, and lodoxamide tromethamine) with placebo.
Finally, 8 RCTs compared topical mast cell stabilizers (sodium cromoglycate, lodoxamide, and nedocromil sodium) with levocabastine, a topical antihistamine.
6,43,44) However, the presence of limbal or corneal disease requires urgent referral--while patients await their appointment, pharmacyonly mast cell stabilisers may be advised such as sodium cromoglycate 2% and lodoxamide 0.
As with VKC, AKC requires long-term therapy with topical mast cell stabilisers such as sodium cromoglycate, lodoxamide and nedocromil to treat the allergic inflammation in mild cases.
A 47-year-old patient with symptoms of redness, blurred vision, burning, and watering in both eyes who was on topical lodoxamide q12h, dexamethasone 0.
Lodoxamide tromethamine and cromolyne sodium should be preferred in severe cases (65).
Topical mast cell stabilizers, such as lodoxamide tromethamine 0.
Ocular mast cell stabilizing drugs such as lodoxamide and cromolyn sodium can block the release of preformed mast cell mediators and reduce the generation of new inflammatory mediators, But these agents also require application 4-6 times per day, and the onset of action is slow Patients often need to use the drops for at least 1 week before experiencing the benefit.
Drugs, such as sodium cromoglycate, nedocromil sodium, pemirolast, and lodoxamide act by stabilizing mast cells.
13-16) The logic of such a treatment might be questioned since sodium cromoglicate is not considered to have any constitutive anti-inflammatory activity; the removal of the stimulus to inflammation should help and better results might be obtained with other mast cell stabilisers/anti-eosinophil drugs such as lodoxamide or nedocromil sodium (both available to AS optometrists).
For chronic and recurrent allergic conjunctivitis, part of an appropriate management approach is the use of 'mast cell stabilisers', (21) with several drugs marketed in the UK (eg, sodium cromoglicate, lodoxamide and nedocromil sodium).