locally advanced

locally advanced

Large or bulky; said of a malignant tumor that has grown substantially at its site of origin.
References in periodicals archive ?
National Institute for Health and Clinical Excellence (NICE) as a treatment for progressive, locally advanced or metastatic differentiated thyroid cancer (papillary, follicular or Hrthle cell) in adults whose disease does not respond to radioactive iodine, in NICE's Final Appraisal Determination (FAD).
s (NASDAQ: ADXS) proprietary Lm-based antigen delivery product, axalimogene filolisbac (ADXS11-001), in combination with chemoradiation as a treatment for high-risk, locally advanced anal cancer were published in the International Journal of Radiation Oncology in an article titled, "Tolerability of ADXS11-001 Lm-LLO Listeria Based Immunotherapy With Mitomycin, Fluorouracil and Radiation for Anal Cancer," the company said.
Celgene announced primary endpoint findings and updated results of secondary endpoints from the phase II international LAPACT trial of Abraxane plus gemcitabine in patients with locally advanced pancreatic cancer.
The product is intended for the treatment of NTRK fusion-positive, locally advanced or metastatic solid tumours in adult and paediatric patients who have either progressed following prior therapies or who have no acceptable standard therapy.
Merck and Pfizer have initiated a Phase III study, JAVELIN Ovarian 100, to evaluate the efficacy and safety of avelumab in combination with, and/or as follow-on (maintenance) treatment to, platinum-based chemotherapy in patients with locally advanced or metastatic disease (Stage III or Stage IV) with previously untreated epithelial ovarian cancer.
WAIKOLOA, HAWAII -- The familiar oral triazole antifungal agent itraconazole is under active investigation for an unexpected use: as adjunctive therapy in patients with locally advanced or metastatic basal cell carcinoma.
Unilab) and Debiopharm International SA (Debiopharm) have signed an exclusive agreement for the distribution and commercialization of Pamorelin 1, 3, and 6-month formulations in the Philippines, for the treatment of locally advanced and metastatic hormone-dependent prostate cancer and as adjuvant to radiotherapy in high-risk localized and locally advanced prostate cancer, and for the treatment of endometriosis (1- and 3-month formulations only).
A significant proportion of patients present with locally advanced prostate cancer with inherent higher risk of local recurrence and systemic relapse after initial treatment.
subsidiary Eisai Europe Limited has received a positive opinion from the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) on the indication expansion of Halaven (generic name: eribulin mesylate, "eribulin") to contribute to earlier-line treatment of patients with locally advanced or metastatic breast cancer who have progressed after at least one chemotherapeutic regimen for advanced disease.
Professor Malcolm Mason, pictured, director of the Wales Cancer Bank and the Cancer Research Wales laboratories, was awarded the William Farr Medal for work on a pivotal trial which examined the effects of adding radiotherapy to standard hormonal therapy when treating locally advanced prostate cancer.
Patients studied in clinical trials of "high-risk prostate cancer" represent a very heterogeneous group; this group includes patients with clinically organ-confined disease (cT1/T2) with high Gleason score, and/or PSA and also those with locally advanced disease.
A study of people with locally advanced lung cancer, found that 33% of patients with partners were alive after three years, compared with just 10% of the single patients.

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