loading dose


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dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

load·ing dose

a comparatively large dose given at the beginning of treatment to start getting the effect of a drug, especially one with slow clearance, thus requiring a long period to achieve stable blood levels without a high initial dose.
Synonym(s): initial dose

loading dose

Initial dose Pharmacology A first dose of a drug administered in excess of the maintenance dose, administered to rapidly achieve therapeutic drug levels. Cf Maintenance dose.

load·ing dose

(lōd'ing dōs)
The first dose of a medicine, which is much larger than the following doses, to reach a therapeutic level more rapidly.

load·ing dose

(lōd-ing' dōs)
Comparatively large dose given at beginning of treatment to start getting the effect of a drug.
Synonym(s): initial dose.

dose

the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.

absorbed dose
that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in Grays.
air dose
the intensity of an x- or gamma-ray beam in air, expressed in coulombs per kilogram.
booster dose
an amount of immunogen (vaccine, toxoid or other antigen preparation), sometimes smaller than the original amount, injected at an appropriate interval after primary immunization to enhance and sustain the immune response to that immunogen.
curative dose (CD)
a dose that is sufficient to restore normal health.
divided dose
a fraction of the total quantity of a drug prescribed to be given at intervals, usually during a 24-hour period.
dose equivalent limits
the limits of ionizing radiation set for radiation workers and the general public by the International Commission on Radiological Protection. For radiology workers this limit for the whole body is 50 mSv.
fatal dose
lethal dose.
dose fractions
in radiation therapy, the small doses given to reach the total radiation dose during the treatment period.
infectious dose 50 (ID50)
that amount of pathogenic microorganisms that will produce infection in 50% of the test subjects.
infective dose (ID)
that amount of pathogenic microorganisms that will cause infection in susceptible subjects.
lethal dose (LD)
the amount of toxin or drug that will kill an animal.
dose level
the amount administered per unit of body weight.
loading dose
the initial large dose of a drug given to bring tissue and fluid levels to an effective concentration quickly. Called also priming dose.
maintenance dose
the smaller doses given to maintain effective levels in body fluids and tissues after the loading dose has achieved the concentration desired.
maximum permissible dose
see dose equivalent limits (above).
median curative dose (CD50)
a dose that abolishes signs in 50% of test animals.
median effective dose (MED)
the dose that produces the desired effect in 50% of the test animals.
median lethal dose (MD50)
the quantity of an agent that will kill 50% of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50% of individuals in a large group or population.
minimum lethal dose (MLD)
the lowest dose which kills all of the test subjects.
dose rate
the amount administered per unit of time.
dose response
1. the incremental change in the subject per unit of additional dose. The response as a function of the dose.
2. the frequency of occurrence of a disease as the intake of the suspected risk factor increases. The relationship is expressed by the proximity of the illustrative curve to the expected relationship.
skin dose
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
tolerance dose
the largest quantity of an agent that may be administered without harm.

loading

administering sufficient quantities of a substance to test a subject's ability to metabolize or absorb it.

loading dose
see loading dose.
References in periodicals archive ?
46] Studies using higher troughs (15-20 mg/L), loading doses or continuous infusions differ with regard to improved clinical or microbiological outcome; however, it is hoped that higher dosing may delay resistance by not selecting those organisms with higher MICs.
In conclusion, we advise a reduced digoxin loading dose in critically ill patients with reduced muscle mass taking medications with known interactions with digoxin.
For the infusible form, loading doses are given on weeks 0, 2, and 4 followed by monthly dosing.
TRITON-TIMI 38 was a head-to-head study comparing prasugrel (60-mg loading dose [LD], followed by a 10-mg once-daily maintenance dose) plus aspirin (ASA) with clopidogrel (300-mg LD, followed by a 75-mg once-daily maintenance dose) plus ASA in 13,608 patients with ACS managed with percutaneous coronary intervention (PCI), a procedure to open blockages in heart arteries, including the use of coronary stenting.
2 mg Lockout interval 10 min 10 min Continuous dose None None Maximum limit in 4 hrs 4 mg 3 mg Loading dose ([dagger]) 0.
including baseline, one hour, four hours and 24 hours post loading dose, as
7) investigated whether LS was effective or not for patients with a low output after cardiac surgery, by administering a loading dose of 12 [micro]g-1 kg in 10 min followed by a continuous infusion dose of 0.
A middle-aged male will typically have a higher load of stored iron and calcium and may benefit from a higher loading dose of mineral chelators, to speed along their removal, followed by a lower dose for long-term maintenance," says Sardi.
A maintenance dose would be one capsule twice a day; a loading dose would be from two to six capsules twice a day.
A low-dose cohort of 38 women received a 25 mg/kg loading dose followed by 1 g/hour after surgery.
Recent studies have shown an increased incidence of thrombocytopenia in those patients receiving a high loading dose of clopidogrel (thienopyridine) with abciximab (IIb/IIIa receptor inhibitor) prior to coronary intervention.
PFA-100 testing was done at the time of hospital diagnosis, before any loading dose of antiplatelet therapy was administered.