lissencephaly type 4

lissencephaly type 4

A neurodevelopmental disorder (OMIM:614019) characterised by lissencephaly, severe brain atrophy, microcephaly and profound mental retardation.

Molecular pathology
Defects in NDE1, which encodes a protein essential for embryonic development of the cerebral cortex, cause lissencephaly type 4.