lipoxin


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lipoxin

(li-pok'sin)
Any of a group of eicosanoids formed by the action of phospholipases on cell membrane phospholipids. Some lipoxins have anti-inflammatory effects, but some promote inflammation and hypersensitivity reactions. See: leukotriene; prostaglandin
References in periodicals archive ?
Lipoxin A4 levels in asthma: relation with disease everity and aspirin sensitivity.
They found that macrophages contain the biochemical tools to not just initiate inflammation, a natural part of the immune response, but also to promote recovery from inflammation by releasing 15-HETE and converting it into lipoxin as the inflammation progresses.
Both mechanisms were controlled by a molecule called lipoxin A4, which is responsible for resolving inflammation.
Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation.
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).
In this study, Dutch researchers measured 15 substances in the blood 1 leukotriene B(4) (LTB[4]), LTC(4), LTC(4), LTE(4), prostaglandin D(2) (PGD [2]), PGE(2), PGF(2) (a), thromboxane B(2), lipoxin A(4), eosinophil cationic protein, eosinophil-derived neurotoxin/eosinophil protein X, eosinophilic peroxidase, myeloperoxidase, histamine and tryptase - and five substances in urine before and up to 72 hours after a bronchial allergen challenge.
They discuss their prevalence, pathophysiology, and existing therapeutic options; what constitutes a lipid and how it is broken down to generate biologically active mediators; mediators like arachidonic acid, platelet-activating factor, and lysophosphatidic acid, how they act, and their role in airway inflammation; the products of arachidonic acid metabolism, such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid; anti-inflammatory lipid mediators such as lipoxin and drug discovery efforts to mimic lipoxin action; enzymes that affect the process of lipid mediator synthesis, their biology, and drug discovery efforts; the role of sphingosine and ceramide; and kinases.
This new aspirin triggered enzyme metabolizes a new aspirin-triggered lipoxin (ATLa), which is more bio-active and possesses better proresolving properties than endogenous lipoxins.
The first of these is the enzyme lipoxygenase (specifically LOX-15) that is present in the epithelia, and generates both an anti-inflammatory and 'pro-inflammatory resolving' prostaglandin-like molecules such as lipoxin A4.
9 /PRNewswire/ -- Berlex, a US Affiliate of Schering AG Germany , announced today that new laboratory results demonstrate that its modified version of the naturally occurring lipoxin molecule exerts potent anti-inflammatory and immunomodulatory effects in Crohn's disease in vivo models and may provide a promising new oral treatment.
Decreased concentrations of antiinflammatory molecules such as IL-10 (4) and lipoxin (5) have also been noted in older, but not in younger, CF patients and may be related instead to secondary events (6, 7).
The mechanism of action appears to be related to inhibition of the production of a protective substance, lipoxin A4, which is synthesized via COX-2.