lipoprotein lipase

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Related to lipoprotein lipase: Lipoprotein lipase deficiency

lip·o·pro·tein li·pase

(lip'ō-prō'tēn lī'pās, lī'pō-),
An enzyme that hydrolyzes one fatty acid from a triacylglycerol; its activity is enhanced by heparin and inactivated by heparinase. It is activated by apolipoprotein C-II; a deficiency of lipoprotein lipase is associated with familial hyperlipoproteinemia type I.
See also: familial lipoprotein lipase inhibitor, clearing factors.

lipoprotein lipase

/lipo·pro·tein li·pase/ (li´pās) an enzyme that catalyzes the hydrolytic cleavage of fatty acids from triglycerides (or di- or monoglycerides) in chylomicrons, very-low-density lipoproteins, and low-density lipoproteins.

lipoprotein lipase (LPL)

an enzyme that plays a key role in breaking down triglycerides present in chylomicrons and very low-density lipoprotein particles, releasing their fatty acids for entry into tissue cells.

lip·o·pro·tein li·pase

(lip'ō-prō'tēn lip'ās)
An enzyme that hydrolyzes one fatty acid from a triacylglycerol; its activity is enhanced by heparin and inactivated by heparinase.
See also: clearing factors


any of the macromolecular complexes that are the form in which lipids are transported in the blood. They consist of a core of hydrophobic lipids covered by a layer of phospholipids and apoproteins, which make the complex water-soluble. There are four main classes of lipoproteins: chylomicrons, in which lipids are transported after a meal from the intestine to tissues, where they are stored or used; very low density lipoproteins (VLDL); low density lipoproteins (LDL); and high density lipoproteins (HDL). VLDL and HDL are produced by both the liver and the intestine; LDL is produced by the metabolism of VLDL.

high density lipoproteins which migrate in the alpha position in paper chromatography. Inherited deficiency of these proteins is described in humans but there is no known animal model of the disease.
lipoprotein factor Xa inhibitor
a blood coagulation inhibitor present in the low density lipoprotein fraction of plasma.
high density lipoprotein (HDL)
a fraction of lipoproteins separable by ultracentrifugation.
intermediate density lipoprotein (IDL)
intermediate in density between LDL and VLDL; migrate in electrophoresis with β-globulins.
lipoprotein lipase
specific lipase hydrolyzing lipoproteins.
lipoprotein lipase deficiency
References in periodicals archive ?
The technology of genomics has al lowed Bensadoun to probe deeper into the workings of lipoprotein lipase than would have been thought possible just a few years ago.
Total lipase is composed of lipoprotein lipase and hepatic lipase, both of which are known to hydrolyze lipids within lipoproteins in the circulation and delivering fatty acid to tissues for storage or oxidation (Kirchgessner et al.
The principal novel finding of this study is that low concentrations of nonfasting plasma triglycerides from genetic variations in the triglyceride-degrading enzyme lipoprotein lipase are associated with reduced all-cause mortality, likely through reduced amounts of cholesterol in remnant lipoproteins.
There is an established link between uric acid and triglyceride production in primary gout (22) and since these patients had been diagnosed with gout it may have decreased the production of lipoprotein lipase (LPL) in the endothelium.
Lipoprotein lipase deficiency causes severe hypertriglyceridaemia due to chylomicronaemia, and leads to recurrent and potentially life-threatening pancreatitis.
The lead products of AMT are an adeno-associated virus (AAV)-based gene therapy for treatment of lipoprotein lipase deficiency and a retroviral product for inflammatory bowel disease (IBD).
One enzyme under genetic scrutiny is lipoprotein lipase, or LPL, which enables this clearance.
Williams notes that shedding pounds shrinks the size of fat cells, which boosts activity of lipoprotein lipase, an enzyme that clears fats from the bloodstream.
Its first product is in registration in EU for Lipoprotein Lipase Deficiency, an orphan condition.
Patients with FCS often have triglyceride levels that are higher than 2,000 mg/dL because they have a genetic defect affecting a key enzyme of fat management, lipoprotein lipase (LPL).

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