lipoprotein lipase

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Related to lipoprotein lipase: Lipoprotein lipase deficiency

lip·o·pro·tein li·pase

(lip'ō-prō'tēn lī'pās, lī'pō-),
An enzyme that hydrolyzes one fatty acid from a triacylglycerol; its activity is enhanced by heparin and inactivated by heparinase. It is activated by apolipoprotein C-II; a deficiency of lipoprotein lipase is associated with familial hyperlipoproteinemia type I.
See also: familial lipoprotein lipase inhibitor, clearing factors.

lipoprotein lipase

/lipo·pro·tein li·pase/ (li´pās) an enzyme that catalyzes the hydrolytic cleavage of fatty acids from triglycerides (or di- or monoglycerides) in chylomicrons, very-low-density lipoproteins, and low-density lipoproteins.

lipoprotein lipase (LPL)

an enzyme that plays a key role in breaking down triglycerides present in chylomicrons and very low-density lipoprotein particles, releasing their fatty acids for entry into tissue cells.

lip·o·pro·tein li·pase

(lip'ō-prō'tēn lip'ās)
An enzyme that hydrolyzes one fatty acid from a triacylglycerol; its activity is enhanced by heparin and inactivated by heparinase.
See also: clearing factors


any of the macromolecular complexes that are the form in which lipids are transported in the blood. They consist of a core of hydrophobic lipids covered by a layer of phospholipids and apoproteins, which make the complex water-soluble. There are four main classes of lipoproteins: chylomicrons, in which lipids are transported after a meal from the intestine to tissues, where they are stored or used; very low density lipoproteins (VLDL); low density lipoproteins (LDL); and high density lipoproteins (HDL). VLDL and HDL are produced by both the liver and the intestine; LDL is produced by the metabolism of VLDL.

high density lipoproteins which migrate in the alpha position in paper chromatography. Inherited deficiency of these proteins is described in humans but there is no known animal model of the disease.
lipoprotein factor Xa inhibitor
a blood coagulation inhibitor present in the low density lipoprotein fraction of plasma.
high density lipoprotein (HDL)
a fraction of lipoproteins separable by ultracentrifugation.
intermediate density lipoprotein (IDL)
intermediate in density between LDL and VLDL; migrate in electrophoresis with β-globulins.
lipoprotein lipase
specific lipase hydrolyzing lipoproteins.
lipoprotein lipase deficiency
References in periodicals archive ?
Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels.
These results highlight the need for clinical trials of new drugs targeted at reducing cholesterol in remnant lipoproteins, perhaps through modulation of lipoprotein lipase activity, to reduce residual cardiovascular risk.
Molecular basis of familial chylomicronemia: mutations in the lipoprotein lipase and apolipoprotein C-II genes.
Lipoprotein lipase activity also is generally lower in patients with type 2 diabetes but increases with normalized glycemia.
Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers.
One enzyme under genetic scrutiny is lipoprotein lipase, or LPL, which enables this clearance.
Williams notes that shedding pounds shrinks the size of fat cells, which boosts activity of lipoprotein lipase, an enzyme that clears fats from the bloodstream.
The company said evinacumab is an investigational monoclonal antibody to angiopoietin-like protein 3 (ANGPTL3) that acts as an inhibitor of lipoprotein lipase and endothelial lipase and appears to play a central role in lipoprotein metabolism.
8 There is also down regulation of lipoprotein lipase, hepatic lipase and the VLDL receptor and upregulation of hepatic acyl-CoA cholesterol acyltransferase (ACAT).
Decreased clearance of TG due to low lipoprotein lipase activity in the absence of insulin.
8] Infection with HIV-1 is known to increase plasma TG levels by decreasing the number of circulating lipoproteins, a process considered to be the result of reduced lipoprotein lipase or by stimulating hepatic lipid synthesis through an increase in hepatic fatty acid synthesis or an increase in re-esterification of fatty acid derived from lipolysis.

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