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lipoprotein lipase |
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lipoprotein lipase /lipo·pro·tein li·pase/ (li´pās) an enzyme that catalyzes the hydrolytic cleavage of fatty acids from triglycerides (or di- or monoglycerides) in chylomicrons, very-low-density lipoproteins, and low-density lipoproteins.
lipoprotein lipase (LPL), an enzyme that plays a key role in breaking down triglycerides present in chylomicrons and very low-density lipoprotein particles, releasing their fatty acids for entry into tissue cells. lipoprotein any of the macromolecular complexes that are the form in which lipids are transported in the blood. They consist of a core of hydrophobic lipids covered by a layer of phospholipids and apoproteins, which make the complex water-soluble. There are four main classes of lipoproteins: chylomicrons, in which lipids are transported after a meal from the intestine to tissues, where they are stored or used; very low density lipoproteins (VLDL); low density lipoproteins (LDL); and high density lipoproteins (HDL). VLDL and HDL are produced by both the liver and the intestine; LDL is produced by the metabolism of VLDL. α-lipoprotein high density lipoproteins which migrate in the alpha position in paper chromatography. Inherited deficiency of these proteins is described in humans but there is no known animal model of the disease. lipoprotein factor Xa inhibitor a blood coagulation inhibitor present in the low density lipoprotein fraction of plasma. high density lipoprotein (HDL) a fraction of lipoproteins separable by ultracentrifugation. intermediate density lipoprotein (IDL) intermediate in density between LDL and VLDL; migrate in electrophoresis with β-globulins. lipoprotein lipase specific lipase hydrolyzing lipoproteins. lipoprotein lipase deficiency see hyperlipoproteinemia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Interestingly, the enzymes for lipid metabolism such as lipoprotein lipase (Lpl, 33-fold), cytosolic acyl-CoA thioesterase (Ctel, 5-fold), and proteasome 26S subunit ATPase-3 (Pmsc3, 4-fold) were increased. He and Herbert used fully anticoagulating intravenous heparin doses to measure lipoprotein lipase levels, intralipid infusions to measure fat clearance, and infusions of radioactive HDL to measure its catabolic rate. The hereditary types of hyperlipoproteinemia are familial lipoprotein lipase deficiency and/or apoprotein C-II deficiency (type I or V), familial hypercholesterolemia (type IIa or IIb), familial dysbetalipoproteinemia type III), familial hypertriglyceridemia (type IV), and combined hypercholesterolemia (type IIa, IIb, and/or IV) (table). |
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