Typical phenotypic changes during pathological fat expansion may include increased adipogenesis (number of differentiated cells and/or quantity of fat accumulation), disruption of lipid metabolism (lipolytic and lipogenic
processes) and disruption of adipokines involved in energy balance (e.
fibroblastic tumor Neural neoplasms Neurofibroma Nerve sheath myxoma Perineurioma Lipogenic
neoplasms Spindle cell lipoma/pleomorphic lipomas Neoplasms of unknown lineage Pleomorphic hyalinizing angiectatic tumor of soft parts Epithelioid sarcoma Table 2.
1995 Transferase Table 2 Lipogenic
Enzymes Regulated by SREBP-1c Enzyme Abbreviation Fatty Acid Synthase FAS Acyl CoA Carboxylase ACC ATP Citrate Lyase ACL Stearoyl CoA Desaturase SCD Malic Enzyme ME Enzyme Function Fatty Acid Synthase Synthesizes fatty acids from acetyl coenzyme A (CoA) and palmitate Acyl CoA Carboxylase Synthesizes malonyl CoA from acetyl CoA ATP Citrate Lyase Converts citrate and CoA to acetyl CoA Stearoyl CoA Desaturase Synthesizes unsaturated fatty acids (oleate) from saturated fatty acids (stearate) Malic Enzyme Generates reducing equivalents (NADPH) for triglyceride synthesis
Li, Effect of Dietary Betaine Supplementation on Lipogenic
Enzyme Activities and Fatty Acid Synthesis mRNA Expression in Finishing Pigs, Animal Feed Sci.
Fatty acid synthase and the lipogenic
phenotype in cancer pathogenesis.
In animal studies we have found an up-regulation of adipogenic and lipogenic
transcription factors in intrauterine growth restricted offspring as well as in offspring of obese mothers (Reprod Sci.
Stimulation of steroidogenic enzymes by IGF-I is most likely mediated through sterol response element-binding proteins-1 (SREBPs-1), a nucleotide sequences found in the promoter regions of several lipogenic
genes in the cholesterol and fatty acid biosynthesis pathways.
Finally, regarding the lipogenic
pathway, FK mRNA expression and protein content were significantly (P < 0.
Carbohydrates trigger lipogenic
enzymes due to the activation of the carbohydrate-responsive element-binding protein (ChREBP), thus favoring the development of obesity .
The tumor cells for myxoid liposarcoma showed membrane immunoreactivity for S100 protein [Figure 3d] and the atypical cells scattered within the varying sized lipogenic
cells of ALT/WDL showed CD34 immunoreactivity [Figure 3e].
A study21 also reported that feeding animals a fat-enriched diet is associated with increased induction of lipogenic
Trigonella foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic