lipodystrophy


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Related to lipodystrophy: lipodystrophy syndrome

lipodystrophy

 [lip″o-dis´tro-fe]
1. any disturbance of fat metabolism.
2. a group of conditions due to defective metabolism of fat, resulting in absence of subcutaneous fat; they may be congenital or acquired and partial or total. (See Atlas 2, Part F.)
congenital generalized lipodystrophy an autosomal recessive condition marked by the virtual absence of subcutaneous adipose tissue, large body size, splenomegaly, hirsutism, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.
intestinal lipodystrophy former name for Whipple's disease.
partial lipodystrophy a condition seen mainly in females in the first decade of life, characterized by symmetrical loss of subcutaneous fat, usually beginning on the face and gradually extending to the chest, neck, back, and upper limbs; this gives the lower part of the body an apparent, and possibly real, adiposity of the buttocks and lower limbs. Some affected patients develop insulin-resistant diabetes mellitus, triglyceridemia, and renal disease.
progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, facial emaciation, and abnormal accumulation of fat about the thighs and buttocks.
total lipodystrophy an autosomal recessive disorder occurring mainly in females, characterized by a generalized loss of subcutaneous fat and extracutaneous adipose tissue, present at birth or appearing later in life, and associated with hepatomegaly with abdominal protuberance, hypoglycemia and insulin-resistant nonketotic diabetes, hyperlipemia, marked elevation of the basal metabolic rate, accelerated somatic growth, advanced bone age, acanthosis nigricans and hirsutism.

lip·o·dys·tro·phy

(lip'ō-dis'trō-fē),
1. Defective metabolism of fat.
2. Abnormal depositions or wastings of adipose tissue, or combinations of these changes, seen in consequence of some protease inhibitor use in AIDS patients.
Synonym(s): cellulite (2) , lipodystrophia
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

/lipo·dys·tro·phy/ (-dis´tro-fe) any disturbance of fat metabolism.
congenital generalized lipodystrophy , congenital progressive lipodystrophy total l.
generalized lipodystrophy  total l.
partial lipodystrophy , progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, beginning with facial emaciation and progressing downward, giving an apparent and possibly real accumulation of fat about the thighs and buttocks.
total lipodystrophy  a recessive condition marked by the virtual absence of subcutaneous adipose tissue, macrosomia, visceromegaly, hypertrichosis, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.

lipodystrophy

[lip′ōdis′trəfē]
Etymology: Gk, lipos + dys, bad, trophe, nourishment
any abnormality in the metabolism or deposition of fats. Kinds of lipodystrophy are congenital total lipodystrophy, familial partial lipodystrophy, insulin lipodystrophy, membranous lipodystrophy, and progressive lipodystrophy.
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Lipodystrophy

lip·o·dys·tro·phy

(lip'ō-dis'trŏ-fē)
Defective metabolism of fat.
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

A condition of disordered fat metabolism. There may be abnormal breakdown of fats with loss of weight, excessive levels of fats in the blood, raised blood sugar levels, enlargement of the liver and abnormal thyroid gland function. In some cases there is breakdown of fat from the upper part of the body and abnormal deposition around the buttocks and thighs. The condition can be caused by prolonged multiple antiretoviral therapy.

lip·o·dys·tro·phy

(lip'ō-dis'trŏ-fē)
1. Defective metabolism of fat.
2. Abnormal depositions or wastings of adipose tissue, or combinations of these changes.
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

(lip´ōdis´trəfē),
n an abnormality in the metabolism or deposition of fats.

lipodystrophy

any disturbance of fat metabolism.

porcine cerebrospinal lipodystrophy
References in periodicals archive ?
Considering the HRQOL among patients with and without lipodystrophy only the domain functional capacity presented reduction in the group with lipodystrophy compared with no lipodystrophy.
Coverage of the Lipodystrophy pipeline on the basis of target, MoA, route of administration and molecule type
2]peak, PA, and sedentary behavior between HIV+ Hispanics with and without lipodystrophy and Non-HIV Hispanics.
LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration.
Hartshorn's mother, however, travels to meet specialist Abhimanyu Garg to discuss her diagnosis, where it is revealed that neither of the women are suffering from lipodystrophy, but instead of cutis laxa, an incurable condition that has other serious implications.
Recent reports in the popular press have highlighted the psychological and social distress that patients experience as a result of lipodystrophy.
How the mutation triggers lipodystrophy is not entirely clear, but this does suggest new therapeutic targets for individuals with the condition.
Citation: "Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal StemCell Exhaustion Syndromes?
A federal advisory panel unanimously supported the approval of tesamorelin, a growth hormone-releasing hormone analogue, for reducing excess abdominal fat in HIV-positive patients with lipodystrophy, a long-term side effect of antiretroviral treatment.
AIDS-related wasting and ART-related lipodystrophy are physical conditions affecting the patient and can be monitored on a regular basis.
Keywords: Berardinelli syndrome, congenital generalized lipodystrophy, insulin resistance.