lipoatrophy


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lipoatrophy

 [lip″o-at´ro-fe]
1. atrophy of subcutaneous fat.
insulin lipoatrophy lipoatrophy in the subcutaneous tissues because of repeated injection of insulin at the same site.

lip·o·at·ro·phy

(lip-ō-at'rō-fē),
Loss of subcutaneous fat, which may be total, congenital, and associated with hepatomegaly, excessive bone growth, and insulin-resistant diabetes.
[G. lipos, fat, + a-, priv. + trophē, nourishment]

lipoatrophy

/lipo·at·ro·phy/ (-at´ro-fe) atrophy of subcutaneous fatty tissues of the body.

lipoatrophy

[lip′ō·at′rəfē]
a breakdown of subcutaneous fat at the site of an insulin injection. It usually occurs after several injections at the same site. Compare lipohypertrophy.
enlarge picture
Lipoatrophy at insulin injection site

lip·o·at·ro·phy

(lip'ō-at'rŏ-fē)
Loss of subcutaneous fat, which may be total, congenital, and associated with hepatomegaly, excessive bone growth, and diabetes.

lipoatrophy

Local shrinkage and loss of the fat under the skin often caused by repeated injections of insulin into the same area in diabetics.

Lawrence,

Robert D., English physician, 1912-1964.
Lawrence-Seip syndrome - loss of subcutaneous fat associated with hepatomegaly, excessive bone growth, and insulin-resistant diabetes. Synonym(s): lipoatrophy

lip·o·at·ro·phy

(lip'ō-at'rŏ-fē)
Loss of subcutaneous fat, which may be total, congenital, and associated with various disorders.

lipoatrophy

atrophy of subcutaneous fatty tissues of the body.
References in periodicals archive ?
BioTime views the European pivotal trial in HIV-associated lipoatrophy as an entryway into a larger market opportunity, like cosmetic facial aesthetics.
Renevia successfully met the primary endpoint in a European pivotal study for the treatment of HIV-associated facial lipoatrophy.
However, treatment is associated to adverse reactions and HIV associated lipodystrophy syndrome characterized by dyslipidemia, glycemic alterations and morphologic alterations as lipoatrophy and lipohypertrophy (3).
Children and adolescents living with HIV undergoing highly active antiretroviral therapy (HAART) often exhibit changes in body fat such as lipoatrophy (loss), lipohypertrophy (central accumulation), or a combination of both.
The factors powering demand for dermal fillers are aging population, increasing expenditure on aesthetics and beauty procedures, introduction of new areas of application such as HIV induced facial lipoatrophy, enhancement of dorsal area of hand and rising demand for non-invasive aesthetic procedures over surgical aesthetic procedures.
Nodular relapsing panniculitis of unknown origin with associated lipoatrophy, fever and lipophagia was originally described as "Weber-Christian disease".
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
To add further, Acrp30 therapy has been demonstrated to reverse insulin resistance in mice manifesting obesity and lipoatrophy [63], which further potentiates the adipocytokine adoption among therapeutic interventions (Acrp30 replacement therapy) to be considered in HIV-infected lypodystrophic patients as well as obesity subjects during instances of metabolic abnormalities.
PATIENTS WITH HIV facial lipoatrophy (FLA) had improved quality of life scores after treatment with a hyaluronic acid (HA) filler, report Derek Ho of the Sacramento VA Medical Center, and coauthors.
Long term (within 6-18 months of ART initiation) adverse effects include lipodystrophy, lipoatrophy, dyslipidemia, diabetes, abnormalities in skin, nail, and hair.
Last but not least is the change of body composition observed in HIV patients in whom peripheral lipoatrophy characterizing thymidine-analogue treated patients, apparently evolves into a sarcopenic/obesity phenotype portraying advanced age.
A single case report of a woman with type1 diabetes on subcutaneous insulin infusion pump suggests HZ as a pre-disposing factor for insulin induced lipoatrophy as well.