lipoatrophy


Also found in: Wikipedia.

lipoatrophy

 [lip″o-at´ro-fe]
1. atrophy of subcutaneous fat.
insulin lipoatrophy lipoatrophy in the subcutaneous tissues because of repeated injection of insulin at the same site.

lip·o·at·ro·phy

(lip-ō-at'rō-fē),
Loss of subcutaneous fat, which may be total, congenital, and associated with hepatomegaly, excessive bone growth, and insulin-resistant diabetes.
[G. lipos, fat, + a-, priv. + trophē, nourishment]

lipoatrophy

/lipo·at·ro·phy/ (-at´ro-fe) atrophy of subcutaneous fatty tissues of the body.

lipoatrophy

[lip′ō·at′rəfē]
a breakdown of subcutaneous fat at the site of an insulin injection. It usually occurs after several injections at the same site. Compare lipohypertrophy.
enlarge picture
Lipoatrophy at insulin injection site

lip·o·at·ro·phy

(lip'ō-at'rŏ-fē)
Loss of subcutaneous fat, which may be total, congenital, and associated with hepatomegaly, excessive bone growth, and diabetes.

lipoatrophy

Local shrinkage and loss of the fat under the skin often caused by repeated injections of insulin into the same area in diabetics.

Lawrence,

Robert D., English physician, 1912-1964.
Lawrence-Seip syndrome - loss of subcutaneous fat associated with hepatomegaly, excessive bone growth, and insulin-resistant diabetes. Synonym(s): lipoatrophy

lip·o·at·ro·phy

(lip'ō-at'rŏ-fē)
Loss of subcutaneous fat, which may be total, congenital, and associated with various disorders.

lipoatrophy

atrophy of subcutaneous fatty tissues of the body.
References in periodicals archive ?
Side-effects that lead to stigmatisation, such as lipoatrophy (stavudine, zidovudine), diarrhoea and flatulence (lopinavir/ritonavir) and gynaecomastia (efavirenz), may be intolerable.
A placebo-controlled trial of daily rosiglitazone involved 71 HIV-positive people with lipoatrophy who had stopped stavudine and zidovudine for at least 24 weeks.
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue), and may affect insulin absorption.
Lipoatrophy in the shoulder region is so characteristic as to allow retrospective diagnosis of LP.
Obesity is considered as the most common predecessor of diabetes and cardiovascular disorders; however, lipoatrophy, i.
The syndrome is characterised by body habitus changes, most commonly a combination of lipoatrophy (LA) (loss of peripheral subcutaneous adipose tissue (SAT), usually in the face, limbs and buttocks) and lipohypertrophy (LH) (visceral adipose tissue (VAT) accumulation, gynaecomastia and, in some cases, lipomatosis, especially in the dorsocervical area, known as a 'buffalo hump').
Activated by insulin, SREBP-1c regulates lipoprotein lipase, fatty acid synthase, peroxisome proliferator-activated receptor (PPARy), and glucokinase, thereby playing an important role in cholesterol, triglyceride, and glucose metabolism, and SREBP-1c adipocyte expression has been linked to lipoatrophy in HIV-infected patients Moreover, indinavir decreases SRBP-1c expression and nuclear localization while promoting apoptosis of adipocytes].
Lipoatrophy is a potential injection-site side effect seen with GA and, to a lesser extent, IFN[beta].