lipoamide


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li·po·ic ac·id

(li-pō'ik as'id),
A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

lipoamide

/lipo·am·ide/ (lip″o-am´īd) the functional form of lipoic acid, linked to the lysine side chain of any of several enzyme complexes that catalyze the oxidative decarboxylation of keto acids.
References in periodicals archive ?
falciparum Thioredoxin reductase (PfTrxR) , belonging to the family of dimeric flavoenzymes, which includes lipoamide dehydrogenase, glutathione reductase, and mercuric ion reductase, is a high molecular weight enzyme that reduces Thioredoxin (Trx) (7).
Lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and thioredoxin.
The result was supported by Reed (1973), who thought that lipoamide dehydrogenase was the flavoprotein component of the [alpha]-keto acid, and which was involved in Krebs cycle promoting energy metabolism.