LPIN1

(redirected from lipin 1)

LPIN1

A gene on chromosome 2p25.1 that encodes a magnesium-dependent phosphatidate phosphatase, which:
(1) Converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum;
(2) Is a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression;
(3) Is involved in adipocyte differentiation; and which
(4) May be involved in mitochondrial fission, converting phosphatidic acid to diacylglycerol.

Molecular pathology
LPIN1 mutations may cause lipodystrophy.
References in periodicals archive ?
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
15) It has been shown that HIF-mediated stimulation of lipin 1 expression causes triglyceride accumulation.
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression.
Lipin 1 is an inducible amplifier of the hepatic PGC-1 alpha/PPARalpha regulatory pathway.
Karen Reue The role of lipin 1 in adipogenesis and lipid metabolism