The approval is based on the results of three phase III studies involving more than 2,600 patients with mixed lipidemia
, which showed that when used in combination with a statin, fenofibric acid improved all three key lipids better than a statin alone.
Our group found a close association between postprandial lipidemia and the Pro12Ala sequence variant of the PPARG gene, with no differences in the baseline concentrations of triglycerides.
In our study, we also found that the association between postprandial lipidemia and the Pro12Ala sequence variant was detected only in patients with the non-E3/E3 APOE genotype.
This mechanism could explain the improvement in glucose clearance and lipidemia
in dyslipidemic hamsters (Narender et al.
The assay is unaffected by icterus (bilirubin <350 mg/L), hemolysis, or lipidemia
Their investigation analyzed data from all the HIV patients in their health system seen between 1996 and 2005 who met the ATP-III definition of dyslipidemia, and compared them each with 10 controls, matched for age, sex, and first year of lipidemia
, who also received lipid-lowering therapy.