lines of Blaschko

lines of Blaschko

(blahs'kō),
a pattern of distribution of skin lesions or pigmentary anomalies; linear on the extremities, S-shaped curves on the abdomen, and V-shaped on the back; thought to result from genetic mosaicism (q.v.) and the interplay of transverse clonal proliferation and longitudinal growth and flexion of the embryo.

lines of Blaschko

Dermatology Alterating stripes of affected and unaffected skin, which are seen in certain skin diseases. Cf Dermatomes.

lines of Blasch·ko

(līnz blas'kō)
A pattern of distribution of skin lesions or pigmentary anomalies; linear on the extremities, S-shaped curves on the abdomen, and V-shaped on the back, thought to result from genetic mosaicism and the interplay of transverse clonal proliferation and longitudinal growth and flexion of the embryo.
References in periodicals archive ?
Doctors use the lines of Blaschko when diagnosing patients and when carrying out surgery, Dr Shergill added.
4) The lines of Blaschko represent clonal postzygotic migration of epidermal and mesenchymal cells of the skin.
The term hypomelanosis of Ito is applied to individuals with skin hypopigmentation along the lines of Blaschko.
2-4] In fact, according to the sine qua non criterion ("presence of skin hypopigmentation in linear streaks or patches involving more than two body segments"[6]) a significant number of individuals can be diagnosed as having HI because of the presence of diffuse or patchy, generalized or limited, linear or spotty skin depigmentation or hypopigmentation distributed along the lines of Blaschko, but also in many other configurations.
2,3,9,10] Proposed Changes to terminology, so far, include the terms pigmentary dysplasia, mosaic dyspigmentation, pigmentary mosaicism of the Ito type, or hypopigmentation along the lines of Blaschko to reflect the disease pathogenesis or recall the cutaneous patterns.
We report a case of a linear fixed drug eruption secondary to naproxen, which appears to follow the lines of Blaschko.