light chain disease


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Related to light chain disease: kappa light chain, LCDD

light chain disease

a type of multiple myeloma in which plasma cell tumors produce only monoclonal light chain proteins. Persons with light chain disease may develop lytic bone lesions, hypercalcemia, impaired kidney function, and amyloidosis. See also gammopathy, heavy chain disease, multiple myeloma.

light chain disease

A nephropathy which presents with nephrotic range proteinuria and rapidly progressive renal failure due to deposition of electron-dense material within tubular and glomerular basement membranes.

Clinical findings
Nephrotic syndrome, heart failure, arrhythmias, liver disease, anorexia, nausea, weight loss, anaemia, increased creatinine, and neurologic disease; similar clinical findings occur in heavy chain deposition.

chain

a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.

chain binomial model
model of an outbreak of an infectious disease in which the outbreak is depicted as a series of steps with a binomial statement of the probability of an outcome at each step.
branched chain
an open chain of atoms, usually carbon, with one or more side chains attached to it.
heavy chain
any of the large polypeptide chains of five classes that, paired with the light chains, make up the antibody molecule. Heavy chains bear the antigenic determinants that differentiate the immunoglobulin classes. See also heavy-chain disease.
J chain
a polypeptide occurring in polymeric IgM and IgA molecules.
light chain
either of the two small polypeptide chains (molecular weight 22,000) that, when linked to heavy chains by disulfide bonds, make up the antibody molecule; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
light chain disease
the overproduction of immunoglobulin light chain molecules by certain B cell tumors (plasmacytomas). See monoclonal gammopathy.
obstetric chain
used in obstetrics in cattle and horses to snare extremities and for traction. Made of rustproof metal with links designed not to kink or to jam. They have a loop link at each end to facilitate single-handed formation of a loop. The links are shaped so that the ring-grip handles used for traction will grip at any point and stay put with the strongest pull.
chain shank
a leather lead with a short section of chain at the proximal end. It can be placed over the horse's nose, through the mouth or across the upper gum for greater control.
side chain
a chain of atoms attached to a larger chain or to a ring.
stallion chain
strong chain, 1-2 ft (0.5 m) long, at the end of a solid lead. For leading a stallion with little chance of his biting through the lead.
chain termination method
References in periodicals archive ?
Balkan nephropathy) as well as more patients with light chain disease to see whether UPE shows equidistant, multiple bands in the [gamma]-globulin region in these patients.
For optimal sensitivity, however, certainly when there is clinical suspicion of light chain disease, an immunologic technique such as IFE is needed (8).
The serum monoclonal immunoglobulins identified by IFE were IgG, n = 34; IgA, n = 11; and IgD, n = 1; there was one case of light chain disease.