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light chain deposition disease

   Also found in: Acronyms 0.01 sec.
light chain deposition disease
Bence-Jones myeloma, light chain disease Oncology A paraproteinemia linked to renal amyloidosis, which occurs in 20% of Pts with immunoproliferative disorders; both are characterized by deposits of fibrillar and nonfibrillar monoclonal light chains in various tissues Clinical Rapidly progressive renal failure due to renal tubular blockage by Bence-Jones proteins, nephrotic syndrome, heart failure, arrhythmias, liver disease, neurologic disease; similar clinical findings are associated with heavy chain deposition


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This spectrum is particularly visible in the kidney, where, in addition to (or instead of) amyloid, a picture of light chain cast nephropathy or nonamyloidotic deposits of light chain deposition disease can often be seen[28-30] The latter deposits are nonfibrillar and are Congo red negative.
 
 
 
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