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ligase chain reaction |
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ligase chain reaction, a type of DNA amplification that uses DNA ligase to link chains and amplify the template containing the sequence in question. ligase an enzyme that repairs single-strand nicks in duplex DNA and covalently joins DNA fragments with complementary, overlapping (called also cohesive or sticky) ends or less efficiently, with blunt ends. Bacteriophage T4 ligase catalyzes the formation of a covalent phosphodiester bond between adjacent 5′-phosphate and 3′-hydroxyl groups in duplex DNA. ligase chain reaction a technique for detecting a specific nucleotide pair in a gene. Called also LCR. ligase chain reaction Ligation amplification reaction Molecular biology A DNA amplification technique for detecting minimal amounts of a known DNA sequence, similar in principle to PCR. See PCR. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Results of tests for Neisseria gonorrhoeae and Chlamydia trachomatis by ligase chain reaction (LCx; Abbot Laboratories, Vienna, Austria) were negative. Ligase Chain Reaction (LCR): A technique for the detection of any defined DNA sequence by amplification of ligation products complementary to the target sequence. |
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