ligand


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ligand

 [li´gand, lig´and]
an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.

lig·and

(lig'and, lī'gand),
1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds, for example, the porphyrin portion of heme, the corrin nucleus of the B12 vitamins.
2. An organic molecule attached to a tracer element, for example, a radioisotope.
3. A molecule that binds to a macromolecule, for example, a ligand binding to a receptor.
4. The analyte in competitive binding assays, such as radioimmunoassay.
5. An atom or group covalently attached to a specified carbon atom in an organic molecule.
[L. ligo, to bind]

ligand

/li·gand/ (li´gand) (lig´and) an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.

ligand

(lī′gənd, lĭg′ənd)
n.
An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex.

ligand

[lig′ənd, lī′gənd]
Etymology: L, ligare, to bind
1 a molecule, ion, or group bound to the central metal atom of a chemical compound, such as the oxygen molecule in oxyhemoglobin, which is bound to the central iron atom.
2 an organic molecule attached to a specific site on a cell surface or to a tracer element. The binding is reversible in a competitive binding assay. It may be the analyte or a cross-reactant. Examples include vitamin B12, a ligand with intrinsic factor as the binding protein, and various antigens, which are ligands with antibody-binding proteins.

li·gand

(lī'gand)
1. An organic molecule attached to a central metal ion by multiple coordinate bonds.
2. An organic molecule attached to a tracer element, e.g., a radioisotope.
3. A molecule that binds to a macromolecule, e.g., a ligand binding to a receptor.
4. The analyte in competitive binding assays, such as radioimmunoassay.
[L. ligo, to bind]

ligand

A MOLECULE or ION that binds to a central chemical entity by non-covalent bonds. A general term for any molecule that is recognized by a surface receptor.

ligand

a molecule able to bind to a specific ANTIBODY and used to distinguish closely similar types of antibody.

li·gand

(lī'gand)
1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds.
2. An organic molecule attached to a tracer element.
3. A molecule that binds to a macromolecule.
[L. ligo, to bind]

ligand

(līgənd),
n 1. a molecule, ion, or group bound to the central atom of a chemical compound, such as the oxygen molecule in hemoglobin, which is bound to the central iron atom.
2. an organic molecule attached to a specific site on a surface or to a tracer element.

ligand

an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or part of a molecule that specifically binds to form a complex with another molecule.
References in periodicals archive ?
Ligand has exclusive agreements with three companies to market and distribute its near-term oncology products, when approved, outside the United States:
In order to demonstrate that the Fas ligand produced by Sertoli cells lends immune privilege to the testes, they transplanted the testes of a strain of mice that can't produce any Fas ligand into a normal rat.
Ligand discovers, develops and markets new drugs that address critical unmet medical needs of patients in the areas of cancer, pain, skin diseases, men's and women's hormone-related diseases, osteoporosis, metabolic disorders, and cardiovascular and inflammatory diseases.
Ligand disclaims any intent or obligation to update these forward-looking statements beyond the date of this release.
In addition, Ligand announced that it has entered into a separate contract sales agreement under which King has been granted the right to and will promote AVINZA during a transition period until closing of the asset purchase agreement.
Dziewanowska, Vice President, Clinical Research at Ligand Pharmaceuticals conducted a retrospective pooled analysis of 1,213 patients in SPIRIT I and II phase III trials to evaluate the presence of biomarker correlates of prolonged survival.
GSK is responsible for the development and registration of products resulting from the collaboration, and Ligand may earn milestone payments of up to $8 million as a product moves through development.
That transition period co-operation includes a minimum number of product sales calls per quarter (100,000 for Organon and 30,000 for Ligand with an aggregate of 375,000 and 90,000 respectively for the transition period) as well as the transition of ongoing promotions, managed care contracts, clinical trials and Key Opinion Leader relationships to Ligand.
The registration statement will also cover the resale of a limited number of shares previously issued by Ligand to directors and a consultant and former employee in reliance on exemptions under federal and state securities laws.
Ligand Pharmaceuticals Incorporated (Pink Sheets:LGND) cancer drug ONTAK(R) (denileukin diftitox) benefits patients with relapsed/refractory T-cell and B-cell non-Hodgkin's lymphoma (NHL) according to Phase II study results presented at the 47th annual meeting of the American Society of Hematology (ASH) in Atlanta.

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