ligand


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

ligand

 [li´gand, lig´and]
an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.

lig·and

(lig'and, lī'gand),
1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds, for example, the porphyrin portion of heme, the corrin nucleus of the B12 vitamins.
2. An organic molecule attached to a tracer element, for example, a radioisotope.
3. A molecule that binds to a macromolecule, for example, a ligand binding to a receptor.
4. The analyte in competitive binding assays, such as radioimmunoassay.
5. An atom or group covalently attached to a specified carbon atom in an organic molecule.
[L. ligo, to bind]

ligand

/li·gand/ (li´gand) (lig´and) an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or molecule that reacts to form a complex with another molecule.

ligand

(lī′gənd, lĭg′ənd)
n.
An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex.

ligand

[lig′ənd, lī′gənd]
Etymology: L, ligare, to bind
1 a molecule, ion, or group bound to the central metal atom of a chemical compound, such as the oxygen molecule in oxyhemoglobin, which is bound to the central iron atom.
2 an organic molecule attached to a specific site on a cell surface or to a tracer element. The binding is reversible in a competitive binding assay. It may be the analyte or a cross-reactant. Examples include vitamin B12, a ligand with intrinsic factor as the binding protein, and various antigens, which are ligands with antibody-binding proteins.

li·gand

(lī'gand)
1. An organic molecule attached to a central metal ion by multiple coordinate bonds.
2. An organic molecule attached to a tracer element, e.g., a radioisotope.
3. A molecule that binds to a macromolecule, e.g., a ligand binding to a receptor.
4. The analyte in competitive binding assays, such as radioimmunoassay.
[L. ligo, to bind]

ligand

A MOLECULE or ION that binds to a central chemical entity by non-covalent bonds. A general term for any molecule that is recognized by a surface receptor.

ligand

a molecule able to bind to a specific ANTIBODY and used to distinguish closely similar types of antibody.

li·gand

(lī'gand)
1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds.
2. An organic molecule attached to a tracer element.
3. A molecule that binds to a macromolecule.
[L. ligo, to bind]

ligand

(līgənd),
n 1. a molecule, ion, or group bound to the central atom of a chemical compound, such as the oxygen molecule in hemoglobin, which is bound to the central iron atom.
2. an organic molecule attached to a specific site on a surface or to a tracer element.

ligand

an organic molecule that donates the necessary electrons to form coordinate covalent bonds with metallic ions. Also, an ion or part of a molecule that specifically binds to form a complex with another molecule.
References in periodicals archive ?
Ligand has exclusive agreements with three companies to market and distribute its near-term oncology products, when approved, outside the United States:
In order to demonstrate that the Fas ligand produced by Sertoli cells lends immune privilege to the testes, they transplanted the testes of a strain of mice that can't produce any Fas ligand into a normal rat.
Ligand discovers, develops and markets new drugs that address critical unmet medical needs of patients in the areas of cancer, pain, skin diseases, men's and women's hormone-related diseases, osteoporosis, metabolic disorders, and cardiovascular and inflammatory diseases.
Ligand has the right to select up to five residual pharmacophores for cancer development from work done in the collaboration on the estrogen and progesterone receptors.
Additionally, Glaxo will make an equity investment in Ligand, acquiring a 6 percent interest in the company.
Ligand disclaims any intent or obligation to update these forward-looking statements beyond the date of this release.
The Rights are designed to assure that all Ligand stockholders receive fair and equal treatment in the event of any proposed takeover of Ligand and to guard against partial tender offers, open market accumulations and other potentially abusive tactics to gain control of Ligand, while not foreclosing a fair acquisition bid for Ligand.
In addition to existing royalty obligations, King will pay Ligand a 15 percent royalty during the first 20 months after the closing date.
The sale of our commercial businesses will create a refocused Ligand built upon our targeted internal research and development effort and broad partnered product pipelines," said Henry F.
SAN DIEGO -- Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) (the "Company" or "Ligand") announced today that it has reached agreement to settle the securities class action litigation filed in the United States District Court for the Southern District of California against the Company and certain of its directors and officers.

Full browser ?