15 showed that intravenous leukotriene receptor antagonists
could produce a 22% improvement in [FEV.
Randomized, placebo controlled trial of effect of a leukotriene receptor antagonist
, montelukast, on tapering inhaled corticosteroids in asthmatic patients.
Leukotriene receptor antagonists
in the treatment of asthma: An update.
The leukotriene receptor antagonist
montelukast in the treatment of chronic idiopathic urticaria.
INV104 (zafirlukast) is a leukotriene receptor antagonist
(LTRA) or anti- leukotriene that reduces inflammation, constriction of the airways, and the build-up of mucus in the lungs.
Even though all three patients were on prophylactic montelukast (Singulair) at the time of aspirin challenge, the leukotriene receptor antagonist
may not provide complete protection in a subset of vulnerable patients.
Leukotrienes have been implicated in the pathogenesis of eustachian tube dysfunction, (1-4) and a leukotriene receptor antagonist
has been shown to be beneficial in preventing the development of middle ear fluid after an inflammatory challenge in the guinea pig model.
Alternative--Cromolyn, leukotriene receptor antagonist
, or theophylline (serum level 5-12 mcg/mL).
Asthma control in children with mild to moderate disease improved consistently and significantly more with an inhaled corticosteroid than with a leukotriene receptor antagonist
in a recent multi center crossover trial.
Zeneca Pharmaceuticals also markets a leukotriene receptor antagonist
under the brand name Accolate.
Focus on zafirlukast: A leukotriene receptor antagonist
for the prophylaxis and chronic treatment of asthma.