leukotriene modifiers

leukotriene modifiers

pharmacologic agents used to interrupt the pathways of leukotriene activation.
See also: antileukotriene.
References in periodicals archive ?
Leukotriene modifiers affect only one biochemical pathway--the lipoxygenase path and resulting leukotriene effects.
2, 2014 /PRNewswire/ -- PharmaPoint: Asthma - Australia Drug Forecast and Market Analysis to 2023 Summary Asthma accounts for approximately 250,000 deaths around the world annually, deaths that otherwise could be easily prevented through appropriate treatment The asthma market saw very slow growth over the past decade, as it has become saturated with relatively efficacious standard therapies, such as short-acting beta-agonists (SABAs), inhaled corticosteroids (ICSs), inhaled corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers, and has also been facing increasing generic competition.
Patients were allowed to continue the use of stable doses of sustained-release theophylline, leukotriene modifiers, anti-immunoglobulin E antibody, or oral glucocorticoids, and were given open-label inhalers of salbutamol or albuterol for use as rescue medication.
From these patients, the researchers looked for individuals who were new users of asthma controller medications, including inhaled corticosteroids, long-acting beta-agonists or leukotriene modifiers, or IACs, and who had continuous enrollment in the IMS system for at least six months prior to having the control medication dispensed.
Leukotriene modifiers are a new form of anti-inflammatory medication used to treat chronic asthma and may also be used as an alternative therapy for treating mild-to-moderate persistent asthma or as combination therapy in moderate asthma.
Patients With Features of Refractory Asthma Cleveland (n = 103) At entry At 1 year Daily symptoms 80% 32% One or more urgent visite 82% 48% Extra controlling medications 50% 92% (long-acting [beta]-agonists, leukotriene modifiers, theophylline) FE[V.
Leukotriene modifiers, as the document notes, have "minimal" data available on their use in pregnancy, although there are some reassuring animal data.
Leukotriene modifiers may potentially be helpful if polyps are present.
The primary care community has extensively employed leukotriene modifiers for exercise-triggered asthma.
For asthma, we examined use of inhaled and systemic corticosteroids, short- and long-acting beta-agonists, cromolyn sodium (and related compounds), methylxanthines, and leukotriene modifiers.
Accolate, also known as Zafirlukast, is one of a new class of "preventer" medicines called leukotriene modifiers which block the effects of leukotriene - natural substances which trigger inflammation and mucus secretion and cause constriction in the lungs leading to an asthma attack.
Treating asthma with leukotriene modifiers alone or in combination with rescue inhalers was associated with better glycemic control.