leukotriene


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leukotriene

 [loo″ko-tri´ēn]
any of a group of compounds derived from unsaturated fatty acids, primarily arachidonic acid, that are extremely potent mediators of immediate hypersensitivity reactions and inflammation, producing smooth muscle contraction, especially bronchoconstriction, increased vascular permeability, and migration of leukocytes to areas of inflammation. Certain leukotrienes are collectively known as SRS-A (slow reacting substance of anaphylaxis), the name given to their potent bronchoconstrictor activity 30 years before their structure was elucidated; they also cause leakage of fluid and proteins from the microvasculature.

leukotriene

/leu·ko·tri·ene/ (-tri´ēn) any of a group of biologically active compounds derived from arachidonic acid that function as regulators of allergic and inflammatory reactions. They are identified by the letters A, B, C, D, and E, with subscript numerals indicating the number of double bonds in each molecule.

leukotriene

(lo͞o′kə-trī′ēn)
n.
Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

leukotriene

substance formed from arachidonic acid which participates in inflammatory reactions, probably as leukotoxin. May act as a slow-reacting substance in anaphylaxis.
References in periodicals archive ?
In conclusion, our pilot project found that a panel comprised of seven urinary biomarkers (8-hydroxyguanosine, dodecanal, leukotriene [C.
Randomized, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients.
Leukotriene D4 receptor antagonist montelukast alleviates protamine sulphate-induced changes in rat urinary bladder.
Our findings suggest that neutrophils play a key role in allergic skin inflammation and that blockade of leukotriene B4 and its receptor might provide a new therapy for eczema," said first author Dr.
Leukotriene receptor antagonists and 5-lipoxygenase inhibitors are used to treat asthma patients, about 15% of whom are sensitive to cyclooxygenase inhibitors.
Leukotriene modifiers: Leukotrienes are potent broncho-constrictors and antileukotriene drugs are either receptor antagonists or enzyme inhibitors.
Leukotrienes have been implicated in the pathogenesis of eustachian tube dysfunction, (1-4) and a leukotriene receptor antagonist has been shown to be beneficial in preventing the development of middle ear fluid after an inflammatory challenge in the guinea pig model.
The Food and Drug Administration has called on manufacturers of leukotriene inhibitors to include safety precautions on their drugs' labeling, because of reports of neuropsychiatric events in patients taking these drugs.
A case of a pregnant woman who died from severe uncontrolled asthma because of fear of taking her leukotriene receptor antagonist, reported to the drug's manufacturer, painfully documents this reality.
Singulair is a leukotriene receptor antagonist commonly prescribed for the prevention and treatment of asthma and for the treatment of allergic rhinitis.
The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma.