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any of a group of compounds derived from unsaturated fatty acids, primarily arachidonic acid, that are extremely potent mediators of immediate hypersensitivity reactions and inflammation, producing smooth muscle contraction, especially bronchoconstriction, increased vascular permeability, and migration of leukocytes to areas of inflammation. Certain leukotrienes are collectively known as SRS-A (slow reacting substance of anaphylaxis), the name given to their potent bronchoconstrictor activity 30 years before their structure was elucidated; they also cause leakage of fluid and proteins from the microvasculature.
leukotriene/leu·ko·tri·ene/ (-tri´ēn) any of a group of biologically active compounds derived from arachidonic acid that function as regulators of allergic and inflammatory reactions. They are identified by the letters A, B, C, D, and E, with subscript numerals indicating the number of double bonds in each molecule.
Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.
substance formed from arachidonic acid which participates in inflammatory reactions, probably as leukotoxin. May act as a slow-reacting substance in anaphylaxis.