leukotriene


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Related to leukotriene: Leukotriene Inhibitors, Leukotriene antagonist

leukotriene

 [loo″ko-tri´ēn]
any of a group of compounds derived from unsaturated fatty acids, primarily arachidonic acid, that are extremely potent mediators of immediate hypersensitivity reactions and inflammation, producing smooth muscle contraction, especially bronchoconstriction, increased vascular permeability, and migration of leukocytes to areas of inflammation. Certain leukotrienes are collectively known as SRS-A (slow reacting substance of anaphylaxis), the name given to their potent bronchoconstrictor activity 30 years before their structure was elucidated; they also cause leakage of fluid and proteins from the microvasculature.

leukotriene

/leu·ko·tri·ene/ (-tri´ēn) any of a group of biologically active compounds derived from arachidonic acid that function as regulators of allergic and inflammatory reactions. They are identified by the letters A, B, C, D, and E, with subscript numerals indicating the number of double bonds in each molecule.

leukotriene

(lo͞o′kə-trī′ēn)
n.
Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

leukotriene

substance formed from arachidonic acid which participates in inflammatory reactions, probably as leukotoxin. May act as a slow-reacting substance in anaphylaxis.
References in periodicals archive ?
His team also found that deleting the receptors on immune cells that bind to leukotriene B4 had a similar effect.
One leukotriene, prostaglandin E2, mediates the formulation of immunoglobulin E (IgE), an antibody responsible for initiating allergic responses.
Although leukotrienes have been implicated in the pathogenesis of eustachian tube dysfunction, our study did not demonstrate that the leukotriene inhibitor montelukast had any effect in clearing middle ear fluid.
Leukotriene receptor antagonists (LTRAs) are suitable options that are given orally
DG-031, but not the placebo, suppressed leukotriene [B.
The leukotriene inhibitors are also used as first-line drugs.
For each child, the team recorded demographic information, a medical history, daily respiratory symptoms (wheeze, persistent cough, chest tightness, and shortness of breath), and medication use (maintenance medications including inhaled and systemic steroids and leukotriene inhibitors, and rescue medications including bronchodilators).
Other new pharmaceutical chemicals projected for strong growth in demand include leukotriene blockers for asthma, monoclonal antibodies for transplant rejection, serotonin 5HT3 antagonists for irritable bowel syndrome and vaccines for influenza.
Blomeke, entitled "Fluorogenic Probes to Detect the A-444C Transversion in the Leukotriene C4 Synthase Promoter" (Clin Chem 2000;46:1438-9), contained errors in the labeling of the LightCycler probes.
Accolate, also known as Zafirlukast, is one of a new class of "preventer" medicines called leukotriene modifiers which block the effects of leukotriene - natural substances which trigger inflammation and mucus secretion and cause constriction in the lungs leading to an asthma attack.
It works by blocking the main cause of inflammation - a chemical called leukotriene.
Zafirlukast, a member of a class of drugs known as leukotriene receptor antagonists, recently was approved by the Food and Drug Administration.