leukotoxin

leukotoxin

 [loo´ko-tok″sin]
a toxin that destroys leukocytes.

leu·ko·cy·to·tox·in

(lū'kō-sī'tō-tok'sin),
Any substance that causes degeneration and necrosis of leukocytes, including leukolysin and leukocidin.
Synonym(s): leukotoxin
[leukocyte + G. toxikon, poison]

leukotoxin

/leu·ko·tox·in/ (loo´ko-tok″sin) a cytoxin destructive to leukocytes.

leukotoxin

[lo̅o̅′kətok′sin]
Etymology: Gk, leukos + toxikon, poison
a substance that can inactivate or destroy leukocytes. leukotoxic, adj.

leu·ko·cy·to·tox·in

(lū'kō-sī'tō-tok'sin)
Any substance that causes degeneration and necrosis of leukocytes, including leukolysin and leukocidin.
Synonym(s): leukotoxin.
[leukocyte + G. toxikon, poison]

leukotoxin

a toxin that destroys leukocytes.
References in periodicals archive ?
No longer can we take an isolated approach of trying to target and block one leukotoxin at a time," says Torres, an associate professor at NYU Langone.
Additional candidates have been highlighted in the literature, including the leukotoxin LukED which targets the human CCR5 receptor (Alonzo, 2013).
aureus, including a leukotoxin comparable to the Panton-Valentine leukocidase as sociated with community-acquired S.
Maraviroc completely blocked the toxic effects of this leukotoxin at doses similar to those used to inhibit HIV infection," Dr.
Larger case series will be needed to best determine if 2C-E is indeed a leukotoxin and to further describe its potential effects on the brain and other organ systems.
As one example, consider that Aggregatibacter (formally Actinobacillus) actinomycetemcomitans produces a leukotoxin that alters the cell membranes of neutrophils and monocytes and thereby alters chemotactic and phagocytic responses.
Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin.
Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase.
Some strains of P multocida and P haemolytica produce a cytotoxin and leukotoxin, respectively, to impair the host immune response.
8] The pathogenesis of A actinomycetemcomitans is not fully understood, but it has been demonstrated that this organism has several putative virulence factors including leukotoxin, collagenase, and chemotaxis inhibiting factor.
Detection of lktA, a gene encoding the leukotoxin expressed by B.
The current focus of Actinobac activities involves the development of pharmaceutical technologies based upon the natural biologic agent leukotoxin (Leukothera(TM)), which targets Leukocyte Function Antigen-1 (LFA-1) on diseased white blood cells.