e coagulase, clumping factors, haemolysin and leukotoxin
, pyogenic toxins comprising staphylococcal enterotoxins, toxic shock syndrome toxin 1, and S.
Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV Leukotoxin
32] The pathogenicity of the microorganism is also underlined by its well-characterized virulence factors, such as leukotoxin
and cytolethal distending toxin, which are suggested to play important roles in altering host inflammatory responses as well as in contributing to periodontal disease progression.
Additional candidates have been highlighted in the literature, including the leukotoxin
LukED which targets the human CCR5 receptor (Alonzo, 2013).
Inhibition of PMN function.
aureus, including a leukotoxin
comparable to the Panton-Valentine leukocidase as sociated with community-acquired S.
Maraviroc completely blocked the toxic effects of this leukotoxin
at doses similar to those used to inhibit HIV infection," Dr.
Prevalence of systemic immunoreactivity to Aggregatibacter actinomycetemcomitans leukotoxin
in relation to the incidence of myocardial infarction.
IL-1beta secretion induced by Aggregatibacter (Actinobacillus) actinomycetemcomitansis mainly caused by the leukotoxin
Rabie G, Lally ET, Shenker BJ, Immunosuppresive Properties of Actinobacillus actinomycetemcomitans Leukotoxin
Prevalence of genes encoding for members of the staphylococcal leukotoxin
family among clinical isolates of Staphylococcus aureus.
As one example, consider that Aggregatibacter (formally Actinobacillus) actinomycetemcomitans produces a leukotoxin
that alters the cell membranes of neutrophils and monocytes and thereby alters chemotactic and phagocytic responses.