In conclusion, leukostasis
(symptomatic hyperleukocytosis) is a medical emergency with a high mortality rate within the first week of presentation if not treated.
Both pulmonary leukostasis and malignant infiltration of the lung have been described in patients with AML (4).
However, clinically defined respiratory events may be directly due Lo the leukemia-related involvement consist of leukostasis, leukemic infiltrates and lysis pneumopathy (5).
This naturally occurring compound is a potential therapeutic agent in the treatment of inflammatory diseases and in vivo leukostasis
A pronounced leukostasis
in vascular channels and interstitial infiltrates of small, blue cells were present in nearly all tissues examined, with pronounced infiltrate in the endocardial surface (Figure 2) of the heart.
Corticosteroids inhibit VEGF secretion in addition to their anti- inflammatory action and ability to suppress leukostasis
Complement (C5a) induced granulocyte aggregation in vitro: a possible mechanism of complement mediated leukostasis
can occur as a result of increased WBC counts >100,000/[mm.
In contrast, leukostasis
due to a nonmalignant extreme leukocytosis is less common, since leukocytes maintain normal size and adhesion characteristics.
Systemic Administration of VEGF Trap Suppresses Vascular Leak and Leukostasis
in the Retinas of Diabetic Rats (Sunday, May 1 2:30 PM - 4:15 PM)
This Phase II project will continue our studies to determine the efficacy of this novel compound on the expression of inflammatory factors, leukostasis
and retinal vascular leakage in animal models of diabetes and AMD.
1,2] Theoretically, immune complexes are formed and circulate, and on entering the pulmonary vascular bed stimulate the release of vasoactive substances that cause the leakage of fluid into alveolar spaces, activation of complement, leukostasis
, and activation of polymorphonuclear neutrophils (PMNs).