leukoreduction


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leukoreduction

(loo″kō-rē-dŭk′shŭn) [Gr. leukos, white, + L. reductio, leading back]
The loss of white blood cells from a unit of packed red cells by filtration of the blood before transfusion. White blood cells in red cell transfusions have been associated with immunosuppression in recipients. Leukoreduction typically lowers the white cell content of packed red cells from about 3 × 109 per unit of blood to about 2.5 × 105 per unit. It has been associated with a decrease in post-transfusion fevers, and, in some studies, with decreased post-transfusion mortality.
References in periodicals archive ?
The association of red cell transfusions with post-operative infections has been shown in randomized clinical trials to be partially mitigated by leukoreduction.
Contract notice: Acquisition of integrated systems for harvesting bags and automatic separation of whole blood by centrifugation and simultaneous expression as well as systems for pooled platelets with integrated leukoreduction filter and use of additive solution, placement of appropriate equipment for this purpose in the service immuno-blood therapy for a period of 36 months.
In addition, incidence of transfusion-related reactions has decreased considerably due to prestorage leukoreduction.
Conducting new RCTs on the effects of leukocyte-containing RBCs in countries that implemented universal leukoreduction of blood products is not possible.
The observational study was conducted during the seven years before and after 2000, when the URMC introduced universal leukoreduction, a process that filters the white cells from blood to be used for transfusions.
Since latent CMV is found in peripheral blood monocytes (7), there are a lot of studies that refer a decrease in the transmission of CMV by leukoreduction of blood components.
Other preventive strategies (such as leukoreduction filtration, saline-washed RBCs, frozen deglycerolised RBCs, etc.
Since patients with high peripheral blast counts may be at greater risk for pulmonary events and tumor lysis syndrome, physicians should consider leukoreduction with hydroxyurea or leukapheresis to reduce the peripheral white count to below 30,000/microL prior to administration of MYLOTARG.
Some costs are direct such as the $35 per bag increase in the cost of blood bags when universal leukoreduction was mandated.
Given the mixed evidence in favor of leukoreduction and the costs involved with adding a new procedure to the blood transfusion process, different countries have adopted different policies towards the practice.
As these new threats emerge, so do new technologies, such as nucleic acid testing to detect HIV, and leukoreduction, which removes white blood cells that can cause posttransfusion complications.