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Related to leukoplakia: leukoplakia vulvae


a disease marked by the development of white thickened patches on the mucous membranes of the cheeks (leukoplakia buccalis), gums, or tongue (leukoplakia lingualis); the patches sometimes form fissures and often become malignant. They may grow into larger patches or form ulcers. Those in the mouth may in time cause pain during swallowing of food or speaking. Leukoplakia affects mostly middle-aged to elderly men, often after prolonged irritation of the mouth from such varying factors as badly fitting dentures or immoderate use of tobacco.

Treatment is aimed at removing any possible cause of physical or chemical irritation; the patient should give up tobacco and possibly also alcohol and extremely hot food. Dental attention may be necessary if teeth are uneven or dentures do not fit properly. Surgical removal of the affected area is relatively simple and may be the best means of preventing further development of the condition.
oral hairy leukoplakia a white filiform to flat patch occurring on the tongue or, rarely, on the buccal mucosa, caused by infection with Epstein-Barr virus and associated with human immunodeficiency virus infection.
leukoplakia vul´vae the presence of hypertrophic grayish-white infiltrated patches on the vulvar mucosa; specific diagnosis is determined by biopsy.


A white patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, a clinical term without histologic connotation.
Synonym(s): smoker's patches
[leuko- + G. plax, plate]


/leu·ko·pla·kia/ (-pla´ke-ah)
1. a white patch on a mucous membrane that will not rub off.

atrophic leukoplakia  lichen sclerosus in females.
oral leukoplakia  white, thick patches on the oral mucosa due to hyperkeratosis of the epithelium, producing favorable conditions for development of epidermoid carcinoma; often occurring on the cheeks (l. bucca´lis), gums, or tongue (l. lingua´lis) .
oral hairy leukoplakia  a white filiform to flat patch on the tongue or the buccal mucosa, caused by infection with Epstein-Barr virus and associated with human immunodeficiency virus infection.
leukoplakia vul´vae 
1. lichen sclerosus in females.
2. any white-appearing lesion of the vulva.


(lo͞o′kə-plā′kē-ə) also


An abnormal condition characterized by white spots or patches on mucous membranes, especially of the mouth and vulva. Also called leukoplasia.


Etymology: Gk, leukos + plakos, plate
a precancerous, slowly developing change in a mucous membrane characterized by thickened, white, firmly attached patches that are slightly raised and sharply circumscribed. They may occur on the penis or vulva. Those appearing on the lips and buccal mucosa are associated with pipe smoking. Malignant potential is evaluated by microscopic study of biopsied tissue. Compare lichen planus. See also lichen sclerosis et atrophicus.
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leukoplakia (vulvar)

Chronic vulvar dystrophy, see there.  

The term leukoplakia continues to be widely used (incorrectly) in the working gynaecological parlance; the error lies in that the term leukoplakia merely refers to the macroscopic appearance of white patches in the postmenopausal vulva, which most commonly correspond to hyper- or parakeratosis and far less commonly to carcinoma in situ or Paget's disease. The portent of vulvar leukoplakia is thus in sharp contrast to oral leukoplakia, which is generally regarded as a pre-malignant lesion.


A potentially precancerous white patch or plaque on a mucosa characterized by epithelial hyperplasia and hyperkeratosis, often caused by chronic irritation; leukoplakia–LP affects the mucosa of oral cavity, upper respiratory tract, vulva, uterine cervix, renal pelvis, urinary bladder; in each site, the significance differs ENT Smoker's keratosis A white plaque or patch on the oral mucosa. See Hairy leukoplakia Ob/Gyn A white plaque or patch on the vaginal mucosa, seen without magnification or acetic acid, and often elevated from surrounding surfaces with a sharp border and Lugol's non-staining Histology Hyperkeratosis, possibly epithelial proliferation. See Speckled leukoplakia.


A white patch of oral mucous membrane that cannot be wiped off and cannot be diagnosed clinically; the spots are smooth, irregular in size and shape, hard, and occasionally fissured. Often associated with pipe smoking. Biopsy may show malignant or premalignant changes.
Synonym(s): leucoplakia.
[leuko- + G. plax, plate]


(loo?ko-pla'ke-a) [ leuko- + Gr. plax, plate + -ia]
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Formation of white spots or patches on the mucous membrane of the tongue or cheek. The spots are smooth, irregular in size and shape, hard, and occasionally fissured. The lesions may become malignant. Synonym: leukokoria; leukoplasia; smoker's tongue See: illustration

leukoplakia buccalis

Leukoplakia of the mucosa of the cheek.
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oral hairy leukoplakia

Leukoplakia of the tongue. It is typically found in immunocompromised patients is a result of Epstein-Barr virus infection.

leukoplakia vulvae

Lichen sclerosis et atrophicus.


A thickened white patch occurring on a mucous membrane, especially inside the mouth, on the lips or on the female genitalia. Leukoplakia is a response to long-term irritation and is a PRECANCEROUS condition that should never be ignored.

leukoplakia (lōō·kō·plaˑ·kē·),

n plaque like white lesion that develops in the oral mucosa. Typically a sign of bodily irritation in response to cigarette smoke or tobacco chewing. In 10% of cases, these lesions are considered precancerous.
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White patch of oral or female genital mucous membrane that cannot be wiped off and cannot be diagnosed clinically as any specific disease entity; in current usage, no histologic connotation.
Synonym(s): leucoplakia.
[leuko- + G. plax, plate]

leukoplakia (loo´kōplā´kēə),

n a white plaque formed on the oral mucosa from surface epithelial cells with an unknown etiology. It is leathery, opaque, and somewhat thickened. Excluded from this are the white lesions of lichen planus, white sponge nevus, burns, thrush, and other clinically recognizable entities. Histologically, hyperkeratosis, acanthosis, and subepithelial and perivascular infiltrate of round cells may be seen. Dyskeratosis may be present. These lesions may progress to malignancy, with cellular atypicism, dyskeratosis, epithelial pearl formation, and infiltration of malignant cells into connective tissue. See also dyskeratosis; hyperkeratosis.
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leukoplakia, hairy,
n a white lesion appearing on the lateral surface of the tongue and occasionally on the buccal mucosa of patients with AIDS. The lesion appears raised, with a corrugated or “hairy” surface as a result of keratin projections.
References in periodicals archive ?
Smokeless tobacco can cause oral leukoplakia (Fig 8) .
Additional data from that study show that AIDS patients withhairy leukoplakia are much more likely to develop a specific type of pneumonia seen in AIDS than are patients in the general AIDS population.
Antiretroviral therapy-with and without protease inhibition-appears to protect against oral candidiasis and has no relationship to the occurrence of oral hairy leukoplakia.
Oral and dermatologic conditions commonly seen with HIV infection Herpes zoster in patients under 50 yr old New-onset psoriasis in patients over 30 yr old Oral candidiasis Oral hairy leukoplakia Recalcitrant vaginal candidiasis New onset of common warts on hands, feet, and beard area in adult Sexually transmitted disease (ie, syphilis, gonorrhea, herpes simplex, chancroid, human papillomavirus) Molluscum contagiosum in adult Numerous nails with fungal infection, especially fingernails Pruritus Petechiae or idiopathic thrombocytopenic purpura Viral exanthem Kaposi's sarcoma
Common visible lesions such as leukoplakia and erythroplakia, which appear as white or red areas in the oral cavity respectively, typically do not transform into malignancies but must be carefully monitored.
DUSA is researching the use of broad area Levulan[R]PDT to treat AKs and prevent squamous cell carcinomas in immunosuppressed solid organ transplant recipients and is supporting research related to oral leukoplakia in collaboration with the National Institutes of Health (NIH).
Her history was significant for chronic obstructive pulmonary disease (COPD); laryngeal leukoplakia had been diagnosed 16 years earlier.
As informative and responsible clinicians, dental hygienists who detect a suspicious leukoplakia and erythroplastic lesion need to inform their dental colleagues so that appropriate referral and further testing are pursued.
Tongue cancer takes several forms - a small ulcer with a raised margin, a white patch, known as leukoplakia, a deep fissure with hard edges or a raised, hard lump.
Six clinicians were aware that leukoplakia may foretell oral cancer, and 5 knew that erythroplakia is a common precursor lesion.
Leukoplakia and erythroplakia are the two most common oral precancerous conditions, and they have varying degrees of risk for malignant transformation.
White lesions that persist after medical therapy represent leukoplakia, and usually they should be excised for histologic analysis.