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leukoencephalopathy

   Also found in: Wikipedia 0.02 sec.
leukoencephalopathy /leu·ko·en·ceph·a·lop·a·thy/ (-en-sef″ah-lop´ah-the) any of a group of diseases affecting the white substance of the brain. The term leukodystrophy is used to denote such disorders due to defective formation and maintenance of myelin in infants and children.
progressive multifocal leukoencephalopathy  a form due to opportunistic infection of the central nervous system by the JC virus, with demyelination occurring usually in the cerebral hemispheres and rarely in the brain stem and cerebellum.

leu·ko·en·ceph·a·lop·a·thy (lk-n-sf-lp-th)

leukoencephalopathy
[lo̅o̅′kō·ən·sef′əlop′əthē]
Etymology: Gk, leukos, white + enkephalos, brain + pathos, disease
any of a group of diseases affecting the white matter of the brain, especially of the cerebral hemispheres, occurring as a rule in infants and children. The term leukodystrophy is used to denote such disorders resulting from a defect in the formation and the maintenance of myelin in infants and children.

leukoencephalopathy
any of a group of diseases affecting the white substance of the brain.


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Three patients in clinical trials had developed progressive multifoeal leukoencephalopathy (PML), a rare nervous system disorder caused by a virus that attacks people with suppressed immunity.
AIDS dementia, central nervous system toxoplasmosis, progressive multifocal leukoencephalopathy, and non-Hodgkin's lymphoma are common causes for the disorders.
Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high dose chemotherapy with autologous stem cell rescue and peritransplantation rituximab.
 
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