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leukocytoclastic vasculitis |
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leukocytoclastic vasculitis [lo̅o̅′kəsī′təklas′tik] an allergic inflammation of blood vessels, characterized by deposits of fragmented cells, nuclear dust, necrotic debris, and fibrin staining in the vessels. Many patients develop skin lesions, particularly on the legs, accompanied by arthralgia and fever. The disorder is seen in rheumatoid arthritis and other diseases. leukocytoclastic vasculitis
leukocytoclastic vasculitis Cutaneous necrotizing vasculitis A form of vasculitis with fragmentation of neutrophil nuclei, immune complex deposition–direct immunofluorescence demonstrates IgG, IgM and complement deposition, that elicits
neutrophilic 'suicide' and deposition of abundant nuclear 'dust', necrotic debris and fibrin, most common in small post-capillary venules; the condition may be local–eg, cutaneous or systemic. See Vasculitis. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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