leukocytoclastic vasculitis


Also found in: Acronyms.

leu·ko·cy·to·clas·tic vas·cu·li·tis

cutaneous acute vasculitis characterized clinically by palpable purpura, especially of the legs, and histologically by exudation of the neutrophils and sometimes fibrin around dermal venules, with nuclear dust and extravasation of red cells; may be limited to the skin or involve other tissues as in Henoch-Schönlein purpura.
See also: cutaneous vasculitis.
[G. leukos, white, + kytos, cell, + klastos, broken, fr. klao, to break]

leukocytoclastic vasculitis

[lo̅o̅′kəsī′təklas′tik]
an allergic inflammation of blood vessels, characterized by deposits of fragmented cells, nuclear dust, necrotic debris, and fibrin staining in the vessels. Many patients develop skin lesions, particularly on the legs, accompanied by arthralgia and fever. The disorder is seen in rheumatoid arthritis and other diseases.
enlarge picture
Leukocytoclastic vasculitis: characteristic skin lesions

allergic vasculitis

A form of nonthrombocytopenic purpura due to a hypersensitivity vasculitis associated with urticaria, erythema, arthritis, gastrointestinal symptoms and renal involvement.

leukocytoclastic vasculitis

Cutaneous necrotizing vasculitis A form of vasculitis with fragmentation of neutrophil nuclei, immune complex deposition–direct immunofluorescence demonstrates IgG, IgM and complement deposition, that elicits neutrophilic 'suicide' and deposition of abundant nuclear 'dust', necrotic debris and fibrin, most common in small post-capillary venules; the condition may be local–eg, cutaneous or systemic. See Vasculitis.

leu·ko·cy·to·clas·tic vas·cu·li·tis

(lū'kō-sī-tō-klas'tik vas'kyū-lī'tis)
Cutaneous acute vasculitis characterized clinically by palpable purpura, especially of the legs, and histologically by exudation of the neutrophils and sometimes fibrin around dermal venules, with nuclear dust and extravasation of red blood cells; may be limited to the skin or involve other tissues as in Henoch-Schönlein purpura.
See also: cutaneous vasculitis
[G. leukos, white, + kytos, cell, + klastos, broken, fr. klao, to break]

leukocytoclastic vasculitis

see hypersensitivity angiitis.
References in periodicals archive ?
Leukocytoclastic vasculitis with perivascular localization and polymorphonuclear leukocytes' accumulation in the dermis was detected in the biopsy specimen taken from the active lesion (Figure 1c).
Ancillary testing usually is not required to make the diagnosis, but when the diagnosis is not clear histopathologic analysis of a skin sample can identify leukocytoclastic vasculitis.
Retrospective analysis of adult patients with cutaneous leukocytoclastic vasculitis.
1997 [53] Mixed type II cryoglobulinemia, leukocytoclastic vasculitis on skin biopsy Dalekos and -- Tsianos, 1994 [54] F: female; ANCA: antineutrophil cytoplasmic antibody; MPO: myeloperoxidase; PR3: proteinase 3.
Generalized pruritus, lichen planus, urticaria, leukocytoclastic vasculitis, necrolytic acral erythema and porphyria cutanea tarda were the important cutaneous manifestations recorded.
Our patient's biopsy results were consistent with a leukocytoclastic vasculitis.
Key words: Henoch-Schonlein purpura, Leukocytoclastic vasculitis, Acute gastroenteritis
The two classic pathologic findings include (1) leukocytoclastic vasculitis of small vessels consisting of fibrinoid necrosis of the vessel wall, extravasated erythrocytes, karyorrhectic debris, and angiocentric inflammation and (2) multiple fibrin thrombi within small vessels in the superficial and deep dermis (Figures 2 through 5).
IV steroid treatment was begun without any significant improvement, so it was decided to perform a second skin biopsy, this time showing leukocytoclastic vasculitis.
The most common forms of vasculitis in the northeast of Iran are Behcet's disease, cutaneous leukocytoclastic vasculitis, and granulomatosis with polyangiitis (Wegener's).
2) The mechanism of bulla formation has been described as due to leukocytoclastic vasculitis or severe dermal oedema.
Other immunologic side effects include thrombocytopenia, gastrointestinal symptoms, rash and cutaneous leukocytoclastic vasculitis.