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A protein released by phagocytes into the blood during a fever. It raises body temperature by acting on the thermoregulatory centers of the anterior hypothalamus
See also: pyrogen
pertaining to or emanating from leukocytes.
protein substances, e.g. interleukin-1, which stimulate the thermoregulator center of the hypothalamus via prostaglandins; produced by bone-marrow derived phagocytes.