leukocyte adhesion deficiency syndrome


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leukocyte adhesion deficiency syndrome

LFA-1 immunodeficiency syndrome A co-dominant or AR, often consanguineous, immune deficiency due to a defect in lymphocyte function-associated antigen–LFA-1, which facilitates cytolytic T-cell mediated killing and helper T-cell response Clinical Inflammation, delayed separation of umbilical cord, recurrent pyogenic infections, pneumonia and poor wound healing due to poor cell adherence, chemotaxis, ↓ respiratory burst. See CD11, CD18, Cell adhesion molecule, Leu-CAM, LFA-1.

Leukocyte adhesion deficiency syndrome

A complement deficiency syndrome characterized by recurrent infections of the skin, mucous membranes, and gastrointestinal tract and the absence of pus formation. This disorder is sometimes apparent at birth when separation of the umbilical cord takes longer than normal.
References in periodicals archive ?
In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndrome.