leukemoid reaction


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leukemoid

 [loo-ke´moid]
having blood counts and sometimes other clinical findings resembling those of leukemia but not due to uncontrolled proliferation of leukocytes.
leukemoid reaction a peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone, with leukocytosis of varying degrees and increased numbers of immature cells in circulation. It may be seen with infections such as tuberculosis, brucellosis, toxoplasmosis, staphylococcal infections, and streptococcal infections; with inflammatory disorders such as glomerulonephritis, rheumatoid arthritis, liver failure, and diabetic acidosis; with tumors and granulomatous infiltration of bone marrow; and with intoxications such as eclampsia, severe burns, and mercury poisoning.

leu·ke·moid re·ac·tion

(lū-kē'moyd rē-ak'shŭn),
A moderate, advanced, or sometimes extreme degree of leukocytosis in the circulating blood, similar to that occurring in various forms of leukemia, but not the result of leukemic disease; usually, there is a disproportionate increase in the number of forms (including immature stages) in one series of leukocytes, and various examples of myelocytic, lymphocytic, monocytic, or plasmocytic leukemoid reaction may be also indistinguishable from leukocytosis that is associated with certain forms of leukemia. Leukemoid reactions are sometimes observed as a feature of: 1) infectious disease caused by certain bacteria and other biologic agents, for example, tuberculosis, diphtheria, and chickenpox; 2) intoxication of various types, for example, eclampsia, serious burns, and mustard gas poisoning; 3) malignant neoplasms, for example, carcinoma of the colon, of the lung, of the kidney, or of other organs; 4) acute hemorrhage or hemolysis.

leukemoid reaction

(lo͞o-kē′moid)
n.
A moderate, advanced, or sometimes extreme degree of leukocytosis that is similar or possibly identical to that occurring in various forms of leukemia but is due to some other cause.

leukemoid reaction

Etymology: Gk, leukos + eidos, form; L, re, again, agere, to act
a clinical syndrome resembling leukemia in which the white blood cell count is elevated in response to an allergy, inflammatory disease, infection, poison, hemorrhage, burn, or severe physical stress. Compare leukemia.
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Leukemoid reaction

leukemoid reaction

Pseudoleukemia Hematology
1. Left shift, see there.
2. Benign abnormal polyclonal proliferation of leukocytes, defined as > 25 x 109/L; LRs reflect a normal BM response to trauma, stress, metabolic disease, drugs, inflammation, connective tissue disease, or malignancy, 2º to secretion of CSF, often associated with immaturity of other cell lines Lab ↑ Leukocyte alkaline phosphatase which is ↓ or absent in leukemia, 'left shift' of myeloid series–↑ bands, metamyelocytes, myelocytes, plasma cells, plasmacytoid lymphocytes, toxic granulation, Döhle inclusion bodies, vacuolization–which implies intracellular bacterial phagocytosis.

leu·ke·moid re·ac·tion

(lū-kē'moyd rē-ak'shŭn)
Leukocytosis similar to that occurring in leukemia, but not the result of leukemic disease. Leukemoid reactions are sometimes observed as a feature of infectious disease (tuberculosis, diphtheria), intoxication (eclampsia, mustard gas poisoning), malignant neoplasms, and acute hemorrhage or hemolysis.
Synonym(s): leukaemoid reaction.

leu·ke·moid re·ac·tion

(lū-kē'moyd rē-ak'shŭn)
Leukocytosis similar to that occurring in leukemia, but not the result of leukemic disease. Sometimes observed as a feature of infectious disease (tuberculosis, diphtheria), intoxication (eclampsia, mustard gas poisoning), malignant neoplasms, and acute hemorrhage or hemolysis.
Synonym(s): leukaemoid reaction.
References in periodicals archive ?
An interesting finding in this study is that respiratory infection was noted to be an independent predictor of the presence of a leukemoid reaction in patients with C difficile colitis.
Also, case patients were older than control patients by a mean of 9 years, which may also account for the higher mortality rate in the leukemoid reaction group.
Overall, however, our data suggest that patients with a positive fecal assay for C difficile complicated by a leukemoid reaction have a more severe systemic illness that leads to prolonged hospitalization and significantly higher mortality rates.
Leukemoid reaction associated with severe diabetic ketoacidosis.
4,5) In fact, C difficile infection has been occasionally associated with leukemoid reactions in patients without HIV infection.
8,9,11-13) Therefore, the leukemoid reactions in these two reported cases, both of whom had extremely advanced AIDS, represent a significant and novel finding.
The absence of previous reports of leukemoid reactions in patients with AIDS in association with any bacterial infection is noteworthy.