APTO-253 is a clinical-stage small molecule therapeutic that acts through induction of the innate tumor suppressor gene Kruppel-like factor 4 (KLF4), and suppression of KLF4 gene expression has been reported as a key driver in the leukemogenesis
of AML and subsets of other hematologic diseases.
Another gene recently described, the HTLV-1 basic leucine zipper factor (HBZ), which is uniformly expressed in ATLL cells, seems to have a more important role in cellular transformation and leukemogenesis
than does p40 tax.
JAK/STAT, Raf/MEK/ERK, P13K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
Mechanisms of leukemogenesis
induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in humans.
Translocations, deletions, inversions, and other rearrangements are structural chromosomal abnormalities that comprise genes with oncogenic potential, which activate specific differentiation or proliferation pathways and cause the progression of leukemogenesis
Furthermore, miR-150 may have an important impact on T-cell development and physiology by targeting NOTCH3, a member of the Notch receptor family that plays important roles in both T-cell differentiation and leukemogenesis
In addition to structural changes involving CBFB, "second-hit" mutations, promoting cell division or cell survival, appear to be necessary for leukemogenesis
The study was specifically designed to collect information on several environmental exposures potentially associated with leukemogenesis
The new function for PTPN11/Shp2 as a tumour suppressor in hepatocellular carcinoma (HCC) stands in contrast to its known oncogenic effect in leukemogenesis
," said Feng.
MOZ is related to the cause of acute myeloid leukaemia, which results from the fusion between MOZ and CBP leading to aberrant chromatin acetylation and leukemogenesis
A table of contents lists the longer entries; among these are acquired aplastic anemia, fibronolysis, folic acid, gene therapy, leukemogenesis
, myeloma, and spleen.
activities of Ikaros may be due to the dysregulation of VPACR-1 induced PKA signaling that results in an Ikaros phosphorylation pattern switch from a non-proliferative to a proliferative state.