leukemic reticuloendotheliosis

reticuloendotheliosis /re·tic·u·lo·en·do·the·li·o·sis/ (-en″do-the″le-o´sis) hyperplasia of reticuloendothelial tissue.

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leukemic reticuloendotheliosis  hairy cell leukemia.

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leukemic reticuloendotheliosis

n.

See hairy cell leukemia.

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leukemic reticuloendotheliosis.

See hairy-cell leukemia.

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Hairy Cell Leukaemia

A low-grade B-cell leukaemia comprising 2% of adult leukaemia, commonly affecting men—male:female ratio, 4:1—age 50-55, leading to progressive pancytopenia; 10% have platelet counts of < 20 x 109/L—US: < 20,000/mm3—20% have thrombocytosis; 1-80% of nucleated RBCs are hairy.
The ‘classic’ or Japanese form—which comprises most cases of HCL—responds better to therapy than the non-classic or variant form
Lab Increased acid phosphatase, especially isoenzyme 5—increased in bone metastases and in Gaucher’s disease
Management First-line therapy: purine analogues 2’-deoxycoformycin (pentostatin) and 2-chlorodeoxyadenosine (cladribine)
Cause of death Infections, gram-negative bacteria, atypical mycobacteria, fungi

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reticuloendotheliosis [rĕ-tik″u-lo-en″do-the″le-o´sis]

hyperplasia of reticuloendothelial tissue.

leukemic reticuloendotheliosis hairy cell leukemia.

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reticuloendotheliosis

a superseded term for neoplasia of hemopoietic precursors. See also blast form of erythremic myelosis.

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avian reticuloendotheliosis

a group of diseases of poultry caused by the REV group of retroviruses, and includes a chronic neoplastic disease of turkeys and chickens, a runting disease in chickens accidentally injected with the virus, and possibly an acute reticulum cell neoplasia. The chronic neoplasia is manifested by nodular tumors in visceral organs.

feline reticuloendotheliosis

see erythremic myelosis, myeloproliferative disease.

leukemic reticuloendotheliosis

leukemia marked by splenomegaly and by an abundance of large, mononuclear abnormal cells with numerous, irregular cytoplasmic projections that give them a flagellated or hairy appearance in the bone marrow, spleen, liver and peripheral blood; called also hairy-cell leukemia.