The effects of dexamethasone on leukemic
cells derived from patients with AML.
Our research attempts to answer one question: If you can push a leukemic
cell to differentiate in the test tube, what then keeps it in a constantly self-renewing, undifferentiated state' in animals or patients with leukemia?
The observed differences could be explained in part by the source of circulating Ang-2, which originates not only from leukemic
blasts but also from other cell types such as endothelial cells.
Malabaricone-A (MAL-A), a plant derived diarylnonanoid, purified from fruit rind of the plant Myristica malabarica, demonstrated prooxidant activity in leukemic
cell lines, with cell death being via increased apoptosis (Manna et al.
Lan and associates (7) reported that leukemic
myeloid sarcoma patients who received chemotherapy had significantly higher median survival rates relative to those who did not receive chemotherapy.
TRAIL expression can also induce the differentiation of surviving leukemic
cells and normal myeloid precursors into mature monocytoids and regulate normal hematopoiesis (6).
The symptoms of acute leukemia, which are a combination of fever, pallor and bleeding, stem from the fact that acute leukemia affects the blood cells through the malignant leukemic
cells, causing anemia, neutropenia (an abnormally low level of white cells called neutrophils) with fever, and a low platelet count which can lead to easy bleeding.
infiltration of the mastoid bone--cytologic examination of exudate in the tympanic cavity as a useful diagnostic method [in Japanese].
Teams across the country have found that by cross-linking the CD23 molecule, they can deliver a negative growth signal to the leukemic
at the Mary Babb Randolph Cancer Center as part of her Honors College Program, Diamond's research focuses on a signaling molecule found in leukemic
cells and believed to contribute to tumor growth.
Among the contributed papers are discussions of automated polarization-discrimination techniques for minimizing lidar-detected skylight background noise, simulating optical resonators for vertical-cavity surface-emitting lasers, and laser and non-coherent light effects on peripheral blood normal and acute lymphoblastic leukemic
cells by using different types of photosensitizers.
Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic
cell line U937" Biochimica et Bio-physica Acta.