leucovorin rescue

leucovorin rescue

Oncology A strategy–administration of a formulation of vitamin B for preventing 'collateral damage' to normal cells when using MTX, an antimetabolite, to treat lymphomas and other malignancies, which may cause BM suppression and GI Sx. See Methotrexate.
References in periodicals archive ?
Furthermore, substantially lower but escalating doses of MTX, with no leucovorin rescue, followed by administration of asparaginase (Capizzi methotrexate) are key elements of "augmented BFM therapy", which has been shown to be efficacious in the treatment of higher-risk childhood ALL (5).
Homocysteine response to MTX treatment in the absence of leucovorin rescue also remains an open issue necessitating further investigation.
The resulting delayed MTX elimination can exacerbate other MTX toxicities because leucovorin rescue is less effective with persistently increased MTX concentrations.
Plasma MTX concentrations are monitored routinely during and after HDMTX administration to determine the dose and duration of leucovorin rescue (8-10).
HD-MTX with leucovorin rescue is used to treat osteosarcoma (8-12 jers [m.
Carboxypeptidase-G2, thymidine and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
He received 4 cycles of high-dose methotrexate (HDMTX) [3] with leucovorin rescue and 2 cycles of cisplatin and doxorubicin, which he tolerated well.
Because MTX and creatinine concentrations were decreasing steadily, the decision was made to complete intravenous hydration at 170 mL/h and leucovorin rescue with 250 mg administered intravenously every 6 h at home until the MTX concentration was < 0.
She underwent leucovorin rescue as the thrombocytopenia was felt to be due to the methotrexate.
Treatment with intravenous HD-MTX and calcium leucovorin rescue was begun.
Calcium leucovorin rescue is administered 24 hours after the start of the MTX administration.