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leucovorin

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.01 sec.
leucovorin /leu·co·vo·rin/ (-vor´in) folinic acid; the calcium salt is used as an antidote for folic acid antagonists, e.g., methotrexate, and in the treatment of megaloblastic anemias due to folic acid deficiency and colorectal carcinoma.
leu·co·vo·rin (lk-vôrn, l-kvr-n)
n.

leucovorin.
leucovorin [loo″ko-vor´in]
leucovorin calcium the calcium salt of folinic acid, used as an antidote for folic acid antagonists, e.g., methotrexate, when there is need to reverse the toxic effects of the latter, in the treatment of megaloblastic anemias due to folic acid deficiency, and as an adjunct in the palliative treatment of colorectal carcinoma; administered orally, intramuscularly, or intravenously.

leucovorin


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Standard first-line treatments including fluorouracil (5-FU) with leucovorin (LV) and irinotecan or oxaliplatin, alone or combined with bevacizumab, have resulted in a median overall survival (mOS) greater than 20 months [3-9].
Of the 348 tumor samples that expressed normal KRAS, one-year progression-free survival rates were 25% and 43% for patients with normal KRAS tumors receiving FOLFIRI (fluorouracil, leucovorin, and irinotecan) and the combination of cetuximab plus FOLFIRI, respectively.
Two major chemicals that most physicians prefer to apply for the best result in colon cancer are fluorouracil (5-FU) and leucovorin.
 
 
 
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