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leucopenia |
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The most common adverse events were anemia, fatigue, hyperbilirubinemia and leucopenia. The most common Grade 3-4 toxicities observed in the CCI and the CCO-arms respectively were skin toxicity (19% vs 30%), leucopenia (11% vs 3%), diarrhea (19% vs 22%), neurotoxicity (3% vs 19%), nausea/vomiting (14% vs 16%), anemia (11% vs 0%) and pain (11% vs 5%). The most frequent grade 3/4 adverse events in the group receiving cisplatin (n=27) regardless of relationship to study medication were leucopenia (56%), asthenia (33%), nausea/vomiting (26%), mucositis (15%), anemia (15%), thrombocytopenia (11%), diarrhea (7%) and anorexia (4%). |
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