leucoencephalopathy


Also found in: Dictionary.
Related to leucoencephalopathy: Progressive multifocal leukoencephalopathy

leu·ko·en·ceph·a·lop·a·thy

(lū'kō-en-sef'ă-lop'ă-thē)
White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Synonym(s): leucoencephalopathy.
[leuko- + G. enkephalos, brain, + pathos, suffering]

leucoencephalopathy

A rare disorder occurring in the late stages of LYMPHOMA or other cancers. Scattered throughout the brain are areas of DEMYELINATION with changes in the supporting (glial) cells characteristic of PAPOVA VIRUS infection. The resulting damage to nerve function causes widespread effects including paralysis, speech and visual defects, DEMENTIA and convulsions and the condition is fatal within a matter of weeks.
References in periodicals archive ?
Progressive multifocal leucoencephalopathy in 47 HIV seropositive patients: neuroimaging with clinical and pathological correlation.
Theoretically, at least, an additional advantage of these agents is their high potency as serotonin 5HT2A receptor antagonists, which may be a useful effect as pro-phylaxis against, and treatment of, progressive multifocal leucoencephalopathy.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL): clinical, neuroimaging, pathological and genetic study of a large Italian family.
MR Imaging of acute intermittent porphyria mimicking reversible posterior leucoencephalopathy syndrome.
The patient was found to have progressive multifocal leucoencephalopathy (PML) - a progressive demyelinating disorder caused by the John Cunningham virus (JCV), which is a DNA papovavirus.
There were no cases of progressive multifocal leucoencephalopathy, cytomegalovirus or pneumocystis pneumonia.
History of progressive multifocal leucoencephalopathy (PML)
X-linked inheritance strongly suggests adrenomyeloneuropathy, Fabry disease, pre-mutation X-fragile diagnosis; dominant inheritance suggests cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), collagen type IV (Col IV) mutation, Nasu-Hakola disease (NHD), adult-onset autosomal dominant leucodystrophies (ADLD) and Alexander disease diagnosis.
A family history must be taken in younger-onset stroke, migraine and dementia patients to correctly identify familial stroke syndromes such as CADASIL and CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leucoencephalopathy, or Maede syndrome).
25) In this study, disease-specific deposits of IgG or activated complement that correlated with the known distribution of either foreign antigen or autoantigen, were detected in virus-infected cells in progressive multifocal leucoencephalopathy, subacute sclerosing panencephalitis and cytomegalovirus encephalitis; in glial limiting membranes in neuromyelitis optica; and in senile plaques in Alzheimer's dementia.
Progressive multifocal leucoencephalopathy (PML) is a demyelinating disease caused by the human neurotropic JC (John Cunningham) virus, a polyomavirus.
Recent interest in established second-line DMT has centred on rare but serious side-effects, particularly progressive multifocal leucoencephalopathy (PML) with natalizumab.