lethal midline granuloma

granuloma /gran·u·lo·ma/ (gran″u-lo´mah) pl. granulomas, granulo´mata   an imprecise term for (1) any small nodular delimited aggregation of mononuclear inflammatory cells, or (2) such a collection of modified macrophages resembling epithelial cells, usually surrounded by a rim of lymphocytes.

---

actinic granuloma  a round lesion with a raised border seen on skin chronically exposed to sunlight.

granuloma annula´re  a benign, self-limited disease consisting of round granulomas of the dermis in groups, with papules or nodules, mainly seen in young girls.

apical granuloma  modified granulation tissue containing elements of chronic inflammation, located adjacent to the root apex of a tooth with infected, necrotic pulp.

coccidioidal granuloma  secondary coccidioidomycosis.

eosinophilic granuloma 

1. Langerhans cell histiocytosis.

2. a disorder similar to eosinophilic gastroenteritis, with localized nodular or pedunculated lesions of the submucosa and muscle walls, especially of the pyloric area of the stomach, caused by infiltration of eosinophils, but without peripheral eosinophilia or allergic symptoms.

3. anisakiasis.

granuloma fissura´tum  a firm, red, fissured, fibrotic granuloma of the gum and buccal mucosa of an edentulous alveolar ridge between the ridge and cheek; caused by an ill-fitting denture.

infectious granuloma  one due to a specific microorganism, as tubercle bacilli.

granuloma inguina´le  a granulomatous venereal disease, usually seen in dark-skinned people, marked by purulent ulceration of the external genitals, caused by Calymmatobacterium granulomatis.

lethal midline granuloma  a rare lethal necrotizing granuloma that destroys the midface; it is nearly always preceded by longstanding nonspecific inflammation of the nose or nasal sinuses, with purulent, often bloody discharge.

lipoid granuloma  xanthoma.

lipophagic granuloma  granuloma with loss of subcutaneous fat.

midline granuloma  lethal midline g.

paracoccidioidal granuloma  paracoccidioidomycosis.

peripheral giant cell reparative granuloma  giant cell epulis.

pyogenic granuloma  a benign, solitary nodule resembling granulation tissue, found anywhere but often in the mouth, usually at the site of trauma as a tissue response to nonspecific infection.

reticulohistiocytic granuloma  a solitary reticulohistiocytoma that is not associated with systemic involvement.

sarcoid granuloma  the granuloma seen with sarcoidosis.

swimming pool granuloma  one that complicates injuries sustained in swimming pools, attributed to Mycobacterium balnei, often healing spontaneously over time.

trichophytic granuloma  tinea corporis, usually on the lower legs, due to Trichophyton infecting hairs at the site, with raised, circumscribed, boggy granulomas, scattered or in chains; lesions are slowly absorbed, or undergo necrosis, leaving scars.

---

lethal midline granuloma

n.

A destructive granulomatous lesion usually arising in the nose or paranasal sinuses and ending in death. Also called malignant granuloma.

---

lethal midline granuloma

A condition confusing to those who read about it and often to those who write about it; LMG is best considered a clinical syndrome rather than a specific histologic lesion; LMG is a destructive lesion of the upper respiratory tract–nose, nasopharynx, palate and midface; it is either idiopathic or 2º to lymphoma, malignant histiocytosis or Wegener's granulomatosis. See Idiopathic midline destructive disease, Malignant histiocytosis, Midline granuloma, Wegener's granulomatosis.