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lethal midline granuloma

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lethal midline granuloma
n.
A destructive granulomatous lesion usually arising in the nose or paranasal sinuses and ending in death. Also called malignant granuloma.
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Because malignant lymphomas are associated with surface crusting, widespread necrosis, and inflammation, they were once considered to be inflammatory lesions, known as lethal midline granulomas or nonhealing granulomas.
Sinonasal lymphoma: a case report by Agarwal, Salil / Ear, Nose and Throat Journal
Classification of nasal granulomas Infectious Mycobacterial: Tuberculosis (human, bovine, or avian); atypical tuberculo- sis; leprosy Bacterial: Rhinoscleroma Treponemal: Syphilis; yaws Fungal: Mucormycosis; aspergillosis; blastomycosis; histoplasmosis; coccidiomycosis; rhinosporidiosis Parasitic: Leishmaniasis Noninfectious Wegener's granulomatosis Sarcoidosis Inclusion granuloma (silicosis; berylliosis) Foreign-body retention Malignant Lethal midline granuloma Nonspecific
Primary nasal tuberculosis: a case report by Ghorpade, Kanchanmala / Ear, Nose and Throat Journal
It is now recognized that the vast majority of cases of lethal midline granuloma represent nasal T-cell lymphomas.
Nasal T-cell lymphoma: Case report and review of diagnostic features by Selvaggi, Kathy / Ear, Nose and Throat Journal
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