lethal factor


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Related to lethal factor: Bacillus anthracis toxin

ge·net·ic le·thal

a disorder that prevents effective reproduction by those affected; for example, Klinefelter syndrome.

ge·net·ic le·thal

(jĕ-net'ik lē'thăl)
A disorder that prevents effective reproduction by those affected.

lethal factor

1. A gene or an abnormality in genetic composition that causes death of a zygote or of an individual before reproductive age.
2. A protein made by Bacillus anthracis. It splits signal transduction proteins within infected cells, resulting in cellular dysfunction and death.
See also: factor
References in periodicals archive ?
In October 2002, Cengent announced the issuance of the first United States Patent describing small-molecule inhibitors of anthrax lethal factor.
Vical's developmental anthrax vaccine is a cationic lipid/DNA formulation that encodes detoxified forms of both Protective Antigen (PA) and Lethal Factor (LF) anthrax proteins.
Semple will be responsible for leading multi-disciplinary teams that are developing novel classes of receptor antagonists for the treatment of asthma, phosphatase inhibitors to treat diabetes/obesity, metalloprotease inhibitors to turn off the lethal factor in anthrax, and kinase inhibitors to cure breast cancer.
Patent and Trademark Office for a family of drug-like molecules that inhibit the activity of anthrax lethal factor.
Vical scientists developed formulated DNA vaccines encoding detoxified forms of two proteins produced by anthrax bacteria, Protective Antigen (PA) and Lethal Factor (LF), that combine to form lethal toxin (Letx), which contributes to the morbidity and mortality of anthrax.
SBI) announced today its award from the National Institutes of Health (NIH) of a Small Business Innovation Research (SBIR) Phase II grant for SBI's continued development of an anthrax lethal factor inhibitor.