lethal factor


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Related to lethal factor: Bacillus anthracis toxin

ge·net·ic le·thal

a disorder that prevents effective reproduction by those affected; for example, Klinefelter syndrome.

ge·net·ic le·thal

(jĕ-net'ik lē'thăl)
A disorder that prevents effective reproduction by those affected.

lethal factor

1. A gene or an abnormality in genetic composition that causes death of a zygote or of an individual before reproductive age.
2. A protein made by Bacillus anthracis. It splits signal transduction proteins within infected cells, resulting in cellular dysfunction and death.
See also: factor
References in periodicals archive ?
The clinical diagnosis was supported by seroconversion to protective antigen and the presence of antibodies against lethal factor.
In a separate study, scientists reveal the three-dimensional shape of lethal factor and the mechanism it uses to sever a protein in cells, an action that triggers the disease.
The WRAIR HIV vaccine, designated LFn-p24, consists of an anthrax-derived polypeptide called Lethal factor (LFn), from which the toxin domain has been removed, and which is fused to the HIV-1 gag p24 protein.
For that amphibian, Saprolegnia is probably the lethal factor in stocked lakes, says Kiesecker.
The Genes To Leads technology has been successfully applied to 15 targets on a contract basis for a growing number of pharmaceutical and biotech companies, and is the basis for Cengent's own highly successful in-house programs for orally active PTP-1B inhibitors (for treatment of type II diabetes and obesity), and anthrax lethal factor inhibitors.
These proteins are known as edema factor (EF), lethal factor (LF), and protective antigen (PA).
It consists of three proteins, the most deadly of which is named lethal factor (LF).