leptomeningeal metastases

leptomeningeal metastases

Oncology CA that has spread to the pia and arachnoid membranes of the brain and spinal cord
References in periodicals archive ?
This is superior to CT-myelography in paediatric cases of leptomeningeal metastases from intracranial tumours.
Less commonly, leptomeningeal metastases may invade the spinal cord.
MRI has the same sensitivity as lumbar puncture in diagnosing leptomeningeal metastases but has only 70% specificity (Kesari & Batchelor, 2003).
Metastatic disease is considered in the following four chapters, which include discussion of the management of brain metastases, spinal metastases, leptomeningeal metastases and dural/skull metastases, and cancer metastasis to the peripheral nervous system.
Gadolinium-enhanced MRI can provide definitive evidence of leptomeningeal metastases, although its reported sensitivity is only 75%.
Bokstein F, Lossos A, Siegal T: Leptomeningeal metastases from solid tumors: A comparison of two prospective series treated with and without intra-cerebrospinal fluid chemotherapy.